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Publikováno v:
FEBS Letters. 588:2944-2951
Although decidualization is crucial for the establishment of successful pregnancy, the molecular mechanism underlying decidualization remains poorly understood. Crystallin αB (CryAB), a small heat shock protein (sHSP), is up-regulated and phosphoryl
Autor:
Łukasz Krych, Camilla Hartmann Friis Hansen, Axel Kornerup Hansen, Dennis Sandris Nielsen, Karsten Buschard
Publikováno v:
Nielsen, D S, Krych, L, Buschard, K, Hansen, C H F & Hansen, A J K 2014, ' Beyond genetics. Influence of dietary factors and gut microbiota on type 1 diabetes ', FEBS Letters, vol. 588, no. 22, pp. 4234-4243 . https://doi.org/10.1016/j.febslet.2014.04.010
Type 1 diabetes (T1D) is an autoimmune disease ultimately leading to destruction of insulin secreting β-cells in the pancreas. Genetic susceptibility plays an important role in T1D etiology, but even mono-zygotic twins only have a concordance rate o
Autor:
Toshiko Kajita, Tsutomu Sasaki, Tatsuo Ishizuka, Ichiro Mori, Itaru Kojima, Kazuo Kajita, Takayuki Hanamoto, Hideyuki Okada, Takashi Sato, Taro Usui, Tadahiro Kitamura, Yoshihiko Kitada, Koichiro Taguchi, Hiroyuki Morita, Takahide Ikeda
Publikováno v:
FEBS Letters. 588:1935-1941
Androgen reduces fat mass, although the underlying mechanisms are unknown. Here, we examined the effect of testosterone on heat production and mitochondrial biogenesis. Testosterone-treated mice exhibited elevated heat production. Treatment with test
Autor:
Klaus Willecke, Anna Beinhauer, Felicitas Bosen, Thomas Franz, Nicola Strenzke, Melanie Schütz
Publikováno v:
FEBS Letters. 588:1795-1801
Distinct mutations in the gap junction protein connexin30 (Cx30) can cause the ectodermal dysplasia Clouston syndrome in humans. We have generated a new mouse line expressing the Clouston syndrome mutation Cx30A88V under the control of the endogenous
Publikováno v:
FEBS Letters. 588:1659-1665
Exposure to ethanol levels reached in circulation during alcohol intoxication (>10mM) constricts cerebral arteries in rats and humans. Remarkably, targets and mechanisms underlying this action remain largely unidentified. Artery diameter is regulated
Autor:
Jing-Yu Leng, Zhirong Zhang, Yi-Juan Zhang, Ming Li, Ai-Guo Sha, Wenbo Deng, Fei Gao, Xiu Xu, Zeng-Ming Yang, Zhen-Ao Zhao, Xiao-Huan Liang
Publikováno v:
FEBS Letters. 588:1580-1589
Glutathione peroxidase 3 (GPX3) is an important member of antioxidant enzymes for reducing reactive oxygen species and maintaining the oxygen balance. Gpx3 mRNA is strongly expressed in decidual cells from days 5 to 8 of pregnancy. After pregnant mic
Publikováno v:
FEBS Letters. 588:1071-1079
Insulin plays an important role in regulation of lipid and glucose metabolism. Retinoic acid receptor-related orphan receptor α (RORα) modulates physiopathological processes such as dyslipidemia and diabetes. In this study, we found overexpression
Publikováno v:
FEBS Letters. 588:1480-1490
Neurons in the enteric nervous system utilize numerous neurotransmitters to orchestrate rhythmic gut smooth muscle contractions. We examined whether electrical synapses formed by gap junctions containing connexin36 also contribute to communication be
Publikováno v:
FEBS Letters. 588:975-980
It is well established that glucocorticoids elevate the production of fibroblast-pneumocyte factor (FPF), which induces type II cells to synthesize surfactant phospholipids. FPF, however, has not been identified and it is not clear whether it is a si
Publikováno v:
FEBS Letters. 588:906-914
Exposure to pro-inflammatory cytokines, such as Angiotensin II, endothelin-1 or TNF leads to endothelial dysfunction, characterized by the reduced production of nitric oxide via endothelial nitric oxide synthase (eNOS). We recently identified the Ca2