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Publikováno v:
FEBS Letters. 590:1614-1629
Here, we investigate the mechanism through which paraoxonase 1 (PON1) may regulate cholesterol efflux. Pretreatment of oxLDL with PON1 (oxLDL-PON1) contributed to the formation of LysoPC. In J774 macrophages, oxLDL-PON1 increased cholesterol efflux b
Autor:
Hiroshi Iwakura, Yosuke Shigematsu, Hiroyuki Koyama, Hiroyuki Ariyasu, Kazuwa Nakao, Kenji Kangawa, Mika Bando, Takashi Akamizu, Hiroshi Hosoda
Publikováno v:
FEBS Letters. 590:992-1001
The mechanisms for supplying octanoic acid for ghrelin acylation in X/A-like cells are incompletely understood. We found that long-chain fatty acids were incorporated at a higher rate in the ghrelin-producing cell line MGN3-1 than in MIN6 cells, in p
Autor:
Pingjin Gao, Ling-Ran Kong, Li-Juan Sheng, Cheng-Chao Ruan, Yu Ma, Dingliang Zhu, Dong-Rui Chen
Publikováno v:
FEBS Letters. 590:769-778
Beta3 adrenergic receptor (ADRB3) mediates vessel relaxation in the endothelium while it modulates lipolysis in the adipose tissue. However, the function and regulation mechanism of ADRB3 in the perivascular adipose tissue (PVAT), especially in hyper
Publikováno v:
FEBS Letters. 590:101-109
Pulmonary arterial hypertension (PAH) is characterized by excessive pulmonary arterial smooth muscle cells (PASMCs) growth, partially in response to PDGF-BB but whether this is dependent on β-catenin (βC) activation is unclear. Compared to healthy
Autor:
Linqiang Li, Jiancheng Yang, Leigh Darryl Quarles, Gwendalyn D. King, Xiaobin Han, Zhousheng Xiao
Publikováno v:
FEBS Letters. 590:53-67
Mechanisms underlying the association between fibroblastic growth factor 23 (FGF-23) and inflammation are uncertain. We found that FGF-23 was markedly up-regulated in LPS/INF-γ-induced proinflammatory M1 macrophages and Hyp mouse-derived peritoneal
Autor:
Nunzia Caporarello, Lucia Frittitta, Marina Scalia, Carmelina Daniela Anfuso, Melania Olivieri, Mario Salmeri, Carla Motta, Cristina Parrino, Gabriella Lupo, Maria Antonietta Toscano
Publikováno v:
FEBS Letters. 589:3969-3976
Cytosolic PLA2 (cPLA2) and Ca(2+)-independent PLA2 (iPLA2) play a significant role in insulin β-cells secretion. Bacterial infections may be responsible of the onset of diabetes. The mechanism by which Staphylococcus aureus infection of INS-1 cells
Autor:
Takanobu Taniguchi, Susanne M. Krug, Michael Fromm, Rafiqul Islam Khan, Yuichi Suzuki, Hatsumi Yoshiki, Tariqul Islam, Ikunobu Muramatsu, Shin-ichiro Karaki, Abu Syed Md Anisuzzaman, Atsukazu Kuwahara, Takashi Yazawa, Junsuke Uwada, Kiyonao Sada
Publikováno v:
FEBS Letters. 589:3640-3647
Impaired intestinal barrier function is one of the critical issues in inflammatory bowel diseases. The aim of this study is to investigate muscarinic cholinoceptor (mAChR)-mediated signaling for the amelioration of cytokine-induced barrier dysfunctio
Publikováno v:
FEBS Letters. 589:3727-3738
LIM-homeodomain (LIM-HD) proteins are evolutionary conserved developmental transcription factors. LIM-HD Lmx1a and Lmx1b orchestrate complex temporal and spatial gene expression of the dopaminergic pathway, and evidence shows they are also involved i
Publikováno v:
FEBS Letters. 589:3739-3748
Parkinson's disease (PD) is a progressive neurodegenerative disorder where dopamine (DA) neurons in the substantia nigra degenerate and die. Since no cure for PD exists, there is a need for disease-modifying drugs. Glial cell line-derived neurotrophi
Autor:
Harinder S. Hundal, Christopher Lipina
Publikováno v:
FEBS Letters. 589:3221-3227
Gangliosides constitute a large family of sialic acid-containing glycosphingolipids which play a key regulatory role in a diverse array of cellular processes, including receptor-associated signalling. Accordingly, the aberrant production of the gangl