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Publikováno v:
Febs Letters
Neonatal brachial plexus injury (NBPI) causes disabling and incurable muscle contractures that are driven by impaired growth of denervated muscles. A rare form of NBPI, which maintains afferent muscle innervation despite motor denervation, does not c
Autor:
Yutaka Tamura, Akiko Suganami, Hiromichi Fujino, Keijo Fukushima, John W. Regan, Yuta Masuda, Suzu Endo, Toshihiko Murayama, Yumi Araki
Publikováno v:
FEBS Letters. 591:3771-3780
The 2-series of prostaglandin E (PGE2) is regarded as a pro-cancer prostanoid, whereas the 1- and 3-series (PGE1 and PGE3) are considered to act as anti-cancer prostanoids. We herein provide possible reasons why PGE1 and PGE3, but not PGE2, exert ant
Publikováno v:
FEBS Letters. 591:527-539
Recent studies have revealed that the sensory nervous system is involved in bone metabolism. However, the mechanism of communication between neurons and osteoblasts is yet to be elucidated. In this study, we investigated the signaling pathways betwee
Autor:
Kenneth P. Nephew, Van T. Hoang, Elizabeth C. Martin, Bridgette M. Collins-Burow, Thomas J. Yan, Adrienne K. Conger, Aaron Buechlein, David F.B. Miller, Matthew E. Burow, Douglas B. Rusch
Publikováno v:
FEBS Letters. 591:382-392
microRNAs (miRNAs) are small noncoding RNA molecules involved in the regulation of gene expression and play critical roles in human malignancies. Next-generation sequencing analysis of the MCF-7 breast cancer cell line overexpressing miR-335-5p and m
Autor:
Masayoshi Imagawa, Eri Yamada, Wataru Horinouchi, Shigehiro Osada, Natsuki Ochiai, Makoto Nishizuka
Publikováno v:
FEBS Letters. 590:4372-4380
KCNMA1 is a pore-forming α-subunit of the large conductance Ca2+ - and voltage-activated K+ channels, referred to as BK channels, which play key roles in various physiological functions. However, the role of KCNMA1 in mature adipocytes remains uncle
Autor:
Meng-Long Zhao, Mei-Nan Yao, Xiao-Huan Liang, Hai-Tin Dou, Wenbo Deng, Yue-Fang Liu, Shu-Yun Li, Zeng-Ming Yang, Jie Liu
Publikováno v:
FEBS Letters. 590:2594-2602
Lipocalin-2 (Lcn2) is a small glycoprotein involved in a number of biological processes such as inflammation and antibacterial response. In our study, Lcn2 is expressed in the subluminal stromal cells at implantation site on day 5 of pregnancy. The e
Publikováno v:
FEBS Letters. 590:1614-1629
Here, we investigate the mechanism through which paraoxonase 1 (PON1) may regulate cholesterol efflux. Pretreatment of oxLDL with PON1 (oxLDL-PON1) contributed to the formation of LysoPC. In J774 macrophages, oxLDL-PON1 increased cholesterol efflux b
Autor:
Linqiang Li, Jiancheng Yang, Leigh Darryl Quarles, Gwendalyn D. King, Xiaobin Han, Zhousheng Xiao
Publikováno v:
FEBS Letters. 590:53-67
Mechanisms underlying the association between fibroblastic growth factor 23 (FGF-23) and inflammation are uncertain. We found that FGF-23 was markedly up-regulated in LPS/INF-γ-induced proinflammatory M1 macrophages and Hyp mouse-derived peritoneal
Autor:
Takanobu Taniguchi, Susanne M. Krug, Michael Fromm, Rafiqul Islam Khan, Yuichi Suzuki, Hatsumi Yoshiki, Tariqul Islam, Ikunobu Muramatsu, Shin-ichiro Karaki, Abu Syed Md Anisuzzaman, Atsukazu Kuwahara, Takashi Yazawa, Junsuke Uwada, Kiyonao Sada
Publikováno v:
FEBS Letters. 589:3640-3647
Impaired intestinal barrier function is one of the critical issues in inflammatory bowel diseases. The aim of this study is to investigate muscarinic cholinoceptor (mAChR)-mediated signaling for the amelioration of cytokine-induced barrier dysfunctio
Autor:
Harinder S. Hundal, Christopher Lipina
Publikováno v:
FEBS Letters. 589:3221-3227
Gangliosides constitute a large family of sialic acid-containing glycosphingolipids which play a key regulatory role in a diverse array of cellular processes, including receptor-associated signalling. Accordingly, the aberrant production of the gangl