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Publikováno v:
FEBS Letters. 581:5500-5504
Nocturnal light pulses induce phase shifts in circadian rhythms and activate cFos expression in the suprachiasmatic nuclei (SCN). We have studied the role of nitric oxide (NO) in the intercellular communication within the dorsal and ventral portions
Publikováno v:
FEBS Letters. 581:5220-5226
We have developed an improved intralumenal digestion method to get a long-term primary culture of rat lymphatic endothelial cells (rLECs) that maintained their original phenotypes. rLECs in vitro under hypoxia retained their original lymphatic proper
Autor:
Laura J. Hampson, Loranne Agius
Publikováno v:
FEBS Letters. 581:3955-3960
Parasympathetic (cholinergic) innervation is implicated in the stimulation of hepatic glucose uptake by portal vein hyperglycaemia. We determined the direct effects of acetylcholine on hepatocytes. Acute exposure to acetylcholine mimicked insulin act
Autor:
Wenhua Zheng, Ruifang Li, Kang Le, Huijie Zhang, Peiqing Liu, Rongbiao Pi, Jie Gao, Ping Wang
Publikováno v:
FEBS Letters. 581:3311-3316
Activation of peroxisome proliferator-activated receptor-alpha (PPAR-alpha) has been recently reported to inhibit vascular inflammatory response and prevent cardiac hypertrophy. However, it is unclear how the activation of PPAR-alpha regulates hypert
Publikováno v:
FEBS Letters. 581:1928-1932
We investigated the effects of advanced glycation end products (AGE) which accumulate in articular cartilage with age in human osteoarthritic chondrocytes. We found AGE-BSA significantly increased MMP-1, -3, and -13, and TNF-alpha in a dose-dependent
Autor:
Abu Asad Chowdhury, M. A. Mazid, Mitsuo Jisaka, Tsutomu Nagaya, Kohji Nishimura, Kohjiro Nagao, Kazushige Yokota
Publikováno v:
FEBS Letters. 580:6885-6890
15-Deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) has been identified as a natural ligand for peroxisome proliferator-activated receptor (PPAR) gamma to promote adipogenesis. However, it remains elusive about the ability of PPARgamma-expressing a
Autor:
Kjetil Taskén, Sven Enerbäck, Line M. Grønning, Miles D. Houslay, George S. Baillie, Martin J. Lynch, Anna Cederberg
Publikováno v:
FEBS Letters. 580:4126-4130
Overexpression of forkhead transcription factor FOXC2 in white adipose tissue (WAT) leads to a lean phenotype resistant to diet-induced obesity. This is due, in part, to enhanced catecholamine-induced cAMP-PKA signaling in FOXC2 transgenic mice. Here
Publikováno v:
FEBS Letters. 580:3617-3623
Protein-mediated LCFA transport across plasma membranes is highly regulated by the fatty acid transporters FAT/CD36 and FABPpm. Physiologic stimuli (insulin stimulation, AMP kinase activation) induce the translocation of one or both transporters to t
Publikováno v:
FEBS Letters. 580:3211-3216
We here provide definitive evidence that ginsenoside-Rg1, the pharmacologically active component of ginseng, is a functional ligand of the glucocorticoid receptor (GR) as determined by fluorescence polarization assay. Rg1 increased the phosphorylatio
Publikováno v:
FEBS Letters. 580:1509-1514
Different C-terminal fragments of parathyroid hormone (PTH)-(1–84) in blood participate in the regulation of calcium homeostasis by PTH-(1–84), and an antagonizing effect for the large carboxyl-terminal parathyroid hormone (C-PTH)-fragment (7–8