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Publikováno v:
FEBS letters. 592(6)
ATPase Inhibitory factor 1 (IF1) is an endogenous regulator of mitochondrial ATP synthase, which is involved in cellular metabolism. Although great progress has been made, biological roles of IF1 and molecular mechanisms of its action are still to be
Publikováno v:
FEBS Letters. 588:975-980
It is well established that glucocorticoids elevate the production of fibroblast-pneumocyte factor (FPF), which induces type II cells to synthesize surfactant phospholipids. FPF, however, has not been identified and it is not clear whether it is a si
Publikováno v:
FEBS Letters. 584:4703-4708
Redox state of pyridine nucleotides of the endoplasmic reticulum (ER) lumen was determined in different nutritional conditions. NADPH-dependent cortisone reduction and NADP+-dependent cortisol oxidation were measured in rat liver microsomes, by utili
Autor:
Liling Zhang, Allen Volchuk
Publikováno v:
FEBS Letters. 584:2298-2304
The p24 protein family have multiple functions in protein transport in the early secretory pathway. In this study we examined the role of p24 proteins in insulin transport. Several members were detected in insulinoma cell lines and rat islets and exp
Publikováno v:
FEBS Letters. 583:3259-3264
We studied the effect of high-fat diet on the expression and activation of the three caveolins in rat skeletal muscle and their association with the insulin signalling cascade. Initial response was characterized by increased signalling through Cav-1
AdipoR1 mediates the anorexigenic and insulin/leptin-like actions of adiponectin in the hypothalamus
Autor:
Bruno Geloneze, Licio A. Velloso, Mario J.A. Saad, Eliana P. Araújo, Andressa Coope, Marciane Milanski, Marcos Antonio Tambascia
Publikováno v:
FEBS Letters. 582:1471-1476
Adiponectin exerts an insulin-sensitizing effect, improving insulin action in peripheral tissues and restraining insulin resistance. Here, we explore the hypothesis that adiponectin can reproduce some of the actions of insulin/leptin in the hypothala
Autor:
Assunta Lombardi, Paola Grasso, Maria Moreno, Fernando Goglia, Rosalba Senese, Pieter de Lange, Antonia Lanni, Elena Silvestri
Publikováno v:
FEBS Letters. 581:5911-5916
We investigated the mechanism by which 3,5-diiodo-l-thyronine (T2) affects skeletal muscle mitochondrial bioenergetic parameters following its acute administration to hypothyroid rats. One hour after injection, T2 increased both coupled and uncoupled
Publikováno v:
FEBS Letters. 581:4884-4890
Aquaporin-4 (AQP4) has been reported to be upregulated post-partum in pregnancy and in early lung development. Several technical challenges exist in measuring AQP4 protein levels, among them sensitivity to detergent solubilization, sample heating and
Autor:
Laura J. Hampson, Loranne Agius
Publikováno v:
FEBS Letters. 581:3955-3960
Parasympathetic (cholinergic) innervation is implicated in the stimulation of hepatic glucose uptake by portal vein hyperglycaemia. We determined the direct effects of acetylcholine on hepatocytes. Acute exposure to acetylcholine mimicked insulin act
Publikováno v:
FEBS Letters. 580:3617-3623
Protein-mediated LCFA transport across plasma membranes is highly regulated by the fatty acid transporters FAT/CD36 and FABPpm. Physiologic stimuli (insulin stimulation, AMP kinase activation) induce the translocation of one or both transporters to t