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Autor:
Masayoshi Imagawa, Eri Yamada, Wataru Horinouchi, Shigehiro Osada, Natsuki Ochiai, Makoto Nishizuka
Publikováno v:
FEBS Letters. 590:4372-4380
KCNMA1 is a pore-forming α-subunit of the large conductance Ca2+ - and voltage-activated K+ channels, referred to as BK channels, which play key roles in various physiological functions. However, the role of KCNMA1 in mature adipocytes remains uncle
Autor:
Meng-Long Zhao, Mei-Nan Yao, Xiao-Huan Liang, Hai-Tin Dou, Wenbo Deng, Yue-Fang Liu, Shu-Yun Li, Zeng-Ming Yang, Jie Liu
Publikováno v:
FEBS Letters. 590:2594-2602
Lipocalin-2 (Lcn2) is a small glycoprotein involved in a number of biological processes such as inflammation and antibacterial response. In our study, Lcn2 is expressed in the subluminal stromal cells at implantation site on day 5 of pregnancy. The e
Autor:
Zhiyong Gao, Jichun Yang, Jing Li, Claudia E. Robert-Cooperman, Chunjiong Wang, Brant R. Burkhardt, Camella G. Wilson, Bryan A. Wolf
Publikováno v:
FEBS Letters. 583:3009-3015
PANDER is a cytokine co-secreted with insulin from islet β-cells. To date, the physiological function of PANDER remains largely unknown. Here we show that PANDER binds to the liver membrane by 125I-PANDER saturation and competitive binding assays. I
MicroRNA-21 protects from mesangial cell proliferation induced by diabetic nephropathy in db/db mice
Publikováno v:
FEBS Letters. 583:2009-2014
Diabetic nephropathy (DN) is a major diabetic complication. But the initiating molecular events triggering DN are unknown. Recent researches have addressed the role of microRNAs in diabetes and its complications. In this study, we looked for microRNA
AdipoR1 mediates the anorexigenic and insulin/leptin-like actions of adiponectin in the hypothalamus
Autor:
Bruno Geloneze, Licio A. Velloso, Mario J.A. Saad, Eliana P. Araújo, Andressa Coope, Marciane Milanski, Marcos Antonio Tambascia
Publikováno v:
FEBS Letters. 582:1471-1476
Adiponectin exerts an insulin-sensitizing effect, improving insulin action in peripheral tissues and restraining insulin resistance. Here, we explore the hypothesis that adiponectin can reproduce some of the actions of insulin/leptin in the hypothala
Publikováno v:
FEBS Letters. 581:5885-5890
Inhibition of the lipid phosphatase SH2-domain containing inositol phosphatase 2 (SHIP2) in L6-C10 muscle cells, in 3T3-L1 adipocytes and in the liver of db/db mice has been shown to ameliorate insulin signal transduction and established SHIP2 as a n
Publikováno v:
FEBS Letters. 580:3211-3216
We here provide definitive evidence that ginsenoside-Rg1, the pharmacologically active component of ginseng, is a functional ligand of the glucocorticoid receptor (GR) as determined by fluorescence polarization assay. Rg1 increased the phosphorylatio
Publikováno v:
FEBS Letters. 573:175-180
Histamine and thrombin cause phosphorylation and activation of endothelial NO-synthase (eNOS) on Ser1177. We tested the role of various protein kinases in mediating this effect in human umbilical vein endothelial cells. Inhibition of the Ca2+/calmodu
Publikováno v:
FEBS letters. 587(12)
Excessive βAR stimulation is an independent factor in inducing pathological cardiac hypertrophy. Here, we report miR-145 regulates both expression and localization of GATA6, thereby protecting the heart against cardiomyocyte hypertrophy induced by i
Publikováno v:
FEBS letters. 586(19)
It is well known that growth hormone (GH)-induced IGF-1 signaling plays a dominant role in postnatal muscle growth. Our previous studies have identified a growth factor, progranulin (PGRN), that is co-induced with IGF-1 upon GH administration. This r