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Publikováno v:
FEBS Letters. 573:175-180
Histamine and thrombin cause phosphorylation and activation of endothelial NO-synthase (eNOS) on Ser1177. We tested the role of various protein kinases in mediating this effect in human umbilical vein endothelial cells. Inhibition of the Ca2+/calmodu
Autor:
Ole Schmitz, Sten Lund, Geoffrey D. Holman, Oluf Pedersen, Søren Dinesen Østergaard, Paul R. Pryor
Publikováno v:
FEBS Letters. 425:472-474
Both insulin and muscle contraction stimulate glucose transport activity. However, contraction stimulation does not involve the insulin signalling intermediate phosphatidylinositol 3-kinase (PI 3-kinase). Protein kinase B (PKB) has recently been iden
Publikováno v:
FEBS letters. 494(3)
Insulin acutely stimulated glucose uptake in rat primary brown adipocytes in a PI3-kinase-dependent but p70S6-kinase-independent manner. Since Akt represents an intermediate step between these kinases, this study investigated the contribution of Akt