Zobrazeno 91 - 100
of 686
pro vyhledávání: ''
Autor:
Soon-Sun Hong, Yoo Wook Kwon, Hyoung Oh Jun, Kyu-Won Kim, Jongheon Shin, Tae-Yoon Kim, Young-Hwa Kim
Publikováno v:
FEBS Letters. 581:4977-4982
Hypoxia regulates a variety of transcription factors including HIF-1, which has been considered a target for anti-angiogenic therapy. While searching for a novel anti-angiogenic agent that would inhibit HIF-1 activity, we identified wondonin, a new b
Publikováno v:
FEBS Letters. 581:4884-4890
Aquaporin-4 (AQP4) has been reported to be upregulated post-partum in pregnancy and in early lung development. Several technical challenges exist in measuring AQP4 protein levels, among them sensitivity to detergent solubilization, sample heating and
Publikováno v:
FEBS Letters. 581:4877-4883
Human resistin, found within atheroma, exerts inflammatory, angiogenic and proliferative effects in vascular cells and may predict coronary events. Here, we investigate mechanisms by which resistin contributes to macrophage ‘foam cell’ formation.
Autor:
Tsuyoshi Matsuo, Eisaku Ogawa, Akihiro Umezawa, Yasuaki Mohri, Ryuhei Okuyama, Katsuhiko Nishimori, Shigeki Kato
Publikováno v:
FEBS Letters. 581:4685-4690
We observed a consistent eye-open at birth (EOB) phenotype in mouse pups homozygous for a leucine-rich repeat containing G-protein coupled receptor 4 (Lgr4) allele deleting the whole transmembrane domain coding region. An in vitro wound-healing scrat
Publikováno v:
FEBS Letters. 581:4080-4084
Serotonin release from preloaded pancreatic β-cells has been used as a marker for insulin release in studying exocytosis from single cells using the amperometric technique. We found that single pancreatic β-cells exhibited oscillations in exocytosi
Publikováno v:
FEBS Letters. 581:2394-2400
Oxidative stress and low grade chronic inflammation are increased in accumulating fat. Our objective was to test whether 4-hydroxynonenal (4-HNE), an end-product of lipid peroxidation, affects cyclooxygenases in 3T3-L1 adipose cells. 4-HNE increased
Autor:
Hiroki Yokota, Kazunori Hamamura
Publikováno v:
FEBS Letters. 581:1769-1774
ATF4 is an essential regulator in osteogenesis as well as in stress responses to the endoplasmic reticulum (ER). We addressed a question: Does ER stress to osteoblasts upregulate ATF4 expression? If so, do they exhibit ATF4-mediated bone remodeling o
Autor:
Toru Fukuda, Waka Bando, Hiroyuki Inose, Satoko Sunamura, Shu Takeda, Atsushi Okawa, Hiroki Ochi, Yoshinori Asou, Akina Haiden
Publikováno v:
FEBS letters. 589(21)
Osteoblastic differentiation is regulated by various factors, including hormones and transcription factors. Runt-related transcription factor 2 (Runx2) is an essential player in osteoblastogenesis and transactivates its molecular target by creating a
Altered epidermal lipid processing and calcium distribution in the KID syndrome mouse model Cx26S17F
Autor:
Katharina vom Dorp, Holger Jastrow, Anna Celli, Elke Winterhager, Peter Dörmann, Theodora M. Mauro, Klaus Willecke, Felicitas Bosen, Debra Crumrine, Philipp Ebel
Publikováno v:
FEBS letters, vol 589, iss 15
The keratitis–ichthyosis–deafness (KID) syndrome is caused by mutations in the gap junctional channel protein connexin 26 (Cx26), among them the mutation Cx26S17F. Heterozygous Cx26S17F mice resemble the human KID syndrome, i.e. exhibiting epider
Autor:
Keiko Nishizawa, Katsumi Doh-ura, Tomohiro Kimura, Ayumi Oguma, Ichiko Nishijima, Yuki Nishimura, Kenta Teruya, Yuji Sakasegawa
Publikováno v:
FEBS letters. 589(15)
The cellular mechanisms behind prion biosynthesis and metabolism remain unclear. Here we show that secretin signaling via the secretin receptor regulates abnormal prion protein formation in prion-infected cells. Animal studies demonstrate that secret