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Publikováno v:
FEBS Letters. 595:3042-3055
Selenium is an essential trace element of interest for its potential role in glucose homeostasis. The present study investigated the impact of selenium supplementation as selenomethionine (SeMet) on insulin secretion in MIN6-K8 cells, a pancreatic β
Hyperproduction of IL-6 caused by aberrant TDP-43 overexpression in high-fat diet-induced obese mice
Publikováno v:
FEBS Letters. 589:1825-1831
Inclusion of Tat-activating regulatory DNA-binding protein-43 (TDP-43) due to hyperphosphorylation or hyperubiquitination is a cause of neurodegenerative disease. Cellular TDP-43 expression is tightly controlled through a negative feedback loop invol
Publikováno v:
Febs Letters
The farnesoid X receptor (FXR) and C/EBP homologous protein (CHOP) have critical functions in hepatic lipid metabolism. Here, we aimed to explore a potential relationship between FXR and CHOP. We fed wild-type (WT) and FXR KO mice a MCD diet (model o
Publikováno v:
FEBS letters. 591(1)
Rat perivascular adipose tissue (PVAT) stores, takes up, and releases norepinephrine (NE; Ayala-Lopez et al. (2014) Pharmacol Res Perspect 2, e00041). We hypothesized that 3T3-L1 adipocytes would exhibit similar behaviors and, thus, could serve as a
Publikováno v:
FEBS letters. 590(18)
Farnesoid X receptor (FXR) has been confirmed to sense bile acids in various tissues. However, its expression in brain neurons remains obscure. In this study, we identified FXR mRNA and protein expression in mouse brain neurons and in mouse/human bra
Publikováno v:
FEBS Letters. 586:996-1003
A high fat diet (HFD) induces substantial cardiac metabolic alteration(s), but the initiating molecular events remain unclear. We assessed the early cardiac energy metabolic changes in C57/BJ mice fed a HFD for 10days. Carbohydrate oxidation was mark
Publikováno v:
FEBS Letters. 585:579-584
Obesity-induced adipose tissue inflammation is characterized by increased macrophage infiltration and cytokine production, and is associated with metabolic disorders. LIGHT/TNFSF14, a member of the TNF superfamily, plays a role in the development of
Autor:
Kazuhiro Ikeda, Hiroo Ogura, Masayoshi Mishina, Toru Tsukui, Masami Muramatsu, Tatsuto Fukushima, Satoshi Inoue
Publikováno v:
FEBS Letters. 584:806-810
Estrogen plays important roles in the reproductive behavior of animals. In the present study, we found that the Grin2d gene of mouse possessed half-sites of the estrogen-responsive element (ERE) in the 3′-untranslated region (UTR). Quantitative PCR
Autor:
Megumi Inuzuka, Kwijun Park, Naohisa Tamura, Kazutoshi Miyashita, Yasutomo Fukunaga, Masakatsu Sone, Daisuke Taura, Naofumi Oyamada, Takuhiro Sonoyama, Kazuwa Nakao
Publikováno v:
FEBS Letters. 583:2067-2070
Anti-fibrotic and organ protective effects of brain natriuretic peptide (BNP) have been reported. In this study, effects of BNP on liver fibrosis were examined in the carbon tetrachloride (CCl(4))-induced liver fibrosis model using BNP-transgenic (Tg
Autor:
Mouaadh Abdelkarim, Brigitte Bois-Joyeux, Bart Staels, Christian Duhem, Saara Laitinen, Hélène Duez, Jean-Louis Danan, Prashant S. Patole
Publikováno v:
FEBS Letters. 583:2031-2036
Here we show that gene expression of the nuclear receptor RORalpha is induced during adipogenesis, with RORalpha4 being the most abundantly expressed isoform in human and murine adipose tissue. Over-expression of RORalpha4 in 3T3-L1 cells impairs adi