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Publikováno v:
FEBS Letters. 595:3042-3055
Selenium is an essential trace element of interest for its potential role in glucose homeostasis. The present study investigated the impact of selenium supplementation as selenomethionine (SeMet) on insulin secretion in MIN6-K8 cells, a pancreatic β
Autor:
Linqiang Li, Jiancheng Yang, Leigh Darryl Quarles, Gwendalyn D. King, Xiaobin Han, Zhousheng Xiao
Publikováno v:
FEBS Letters. 590:53-67
Mechanisms underlying the association between fibroblastic growth factor 23 (FGF-23) and inflammation are uncertain. We found that FGF-23 was markedly up-regulated in LPS/INF-γ-induced proinflammatory M1 macrophages and Hyp mouse-derived peritoneal
Autor:
Jing-Yu Leng, Zhirong Zhang, Yi-Juan Zhang, Ming Li, Ai-Guo Sha, Wenbo Deng, Fei Gao, Xiu Xu, Zeng-Ming Yang, Zhen-Ao Zhao, Xiao-Huan Liang
Publikováno v:
FEBS Letters. 588:1580-1589
Glutathione peroxidase 3 (GPX3) is an important member of antioxidant enzymes for reducing reactive oxygen species and maintaining the oxygen balance. Gpx3 mRNA is strongly expressed in decidual cells from days 5 to 8 of pregnancy. After pregnant mic
Publikováno v:
FEBS Letters. 588:1071-1079
Insulin plays an important role in regulation of lipid and glucose metabolism. Retinoic acid receptor-related orphan receptor α (RORα) modulates physiopathological processes such as dyslipidemia and diabetes. In this study, we found overexpression
Publikováno v:
FEBS Letters. 586:1306-1311
The existence of peripheral oscillators has been shown, and they are critically important for organizing the metabolism of the whole body. Here we show that mice deficient in mPer2 markedly increase circulatory levels of insulin compared with wild ty
Publikováno v:
FEBS Letters. 586:89-95
Latrunculin depolymerizes and jasplakinolide polymerizes β-cell actin microfilaments. Both increase insulin secretion when Ca(2+) enters β-cells during depolarization by glucose, sulfonylureas or potassium. Mouse islets were held hyperpolarized wit
Publikováno v:
FEBS Letters. 585:2587-2591
Recently, we identified ganglioside GM2 activator protein (GM2AP) as a novel adipokine, and revealed that treatment of cultured cells with GM2AP impairs insulin signal transduction. The aim of this study was to examine the impact of GM2AP on glucose
Publikováno v:
FEBS Letters. 585:2137-2143
PANcreatic-DERived factor (PANDER, FAM3B) is a member of the FAM3 family of cytokine molecules that were initially described in 2002. PANDER expression is primarily localized to the endocrine pancreas and is secreted from both pancreatic α and β-ce
Autor:
Byung-Sam Kim, Ha-Jung Kim, Hye-Sun Choi, Hong-Min Kim, Chu-Sook Kim, Choon-Soo Jeong, Rina Yu, Teruo Kawada
Publikováno v:
FEBS Letters. 585:2285-2290
HVEM is a member of the TNF receptor superfamily that plays a role in the development of various inflammatory diseases. In this study, we show that HVEM deficiency attenuates adipose tissue inflammatory responses and glucose intolerance in diet-induc
Autor:
Andreas Schäffler, Sabrina Bauer, Christa Buechler, Christoph Dorn, Claus Hellerbrand, Josef Wanninger, Thomas S. Weiss, Kristina Eisinger, Roland Walter, Markus Neumeier
Publikováno v:
FEBS Letters. 585:1338-1344
Transforming growth factor (TGF) β is the central cytokine in fibrotic liver diseases. We analyzed whether hepatoprotective adiponectin directly interferes with TGFβ1 signaling in primary human hepatocytes (PHH). Adiponectin induces the TGFβ decoy