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Publikováno v:
FEBS letters
Fas (CD95) belongs to the superfamily of the tumor necrosis factor (TNF) receptors. Besides its key role in apoptosis, Fas contributes to non-apoptotic pathways such as cell proliferation and inflammation. In 3T3-L1 adipocytes, activation of Fas by F
Publikováno v:
FEBS Letters. 311:161-164
The exposure of mouse peritoneal macrophages to cholesterol linoleate-containing, artificial lipoproteins can lead to intracellular ceroid accumulation. This can be used as a model to study the role of oxidation in macrophage uptake of lipoproteins c
Publikováno v:
FEBS Letters. 301:277-281
We purified a serum calcium-decreasing factor, which showed chymotrypsin-like protease activity, from porcine pancreas to homogeneity. The factor administered to mice intravenously at a dose of 20 micrograms/kg b.w. decreased serum calcium by 15%. Tr
Publikováno v:
FEBS Letters. 291:113-116
Expression of a transforming Ha-ras by dexamethasone in NIH3T3 cells transfected with a glucocorticoid-inducible Ha-ras construct results in a rapid desensitization of the intracellular Ca(2+)-mobilizing system to bombesin. This effect precedes the d
Publikováno v:
FEBS Letters. 287:93-96
Mouse thymocytes incubated in vitro with increasing concentrations of interleukin-1 (IL-1) in the presence of phytohemagglutinin (PHA) exhibited a dose-dependent increase in cell proliferation, as measured by [3H]thymidine incorporation. Under these
Publikováno v:
FEBS letters. 582(28)
Insulin resistant states are associated with an increase in the beta cell mass and also high levels of circulating insulin. Ultimately the beta cells undergo a failure that leads to diabetes. At this stage, a question arises if those persistent high
Autor:
Wendy M. Macfarlane, S.C. Campbell, C. Landy, James Shaw, T. Ali, Clive S. Butler, William F. Ferris, Claire Marriott, A Aldibbiat
Publikováno v:
FEBS letters. 582(15)
The present study investigated the role of selenium in the regulation of pancreatic beta-cell function. Utilising the mouse beta-cell line Min6, we have shown that selenium specifically upregulates Ipf1 (insulin promoter factor 1) gene expression, ac
Publikováno v:
FEBS letters. 582(1)
Adiponectin is an abundantly expressed adipokine in adipose tissue and has direct insulin sensitizing activity. A decrease in the circulating levels of adiponectin by interactions between genetic factors and environmental factors causing obesity has
Publikováno v:
FEBS letters. 581(5)
Diabetes Mellitus is found with increasing frequency in iron overload patients with hemochromatosis. In these conditions, the pancreas shows predominant iron overload in acini but also islet beta-cells. We assess glucose homeostasis status in iron-ov
Publikováno v:
FEBS letters. 581(3)
We examined the effects of prostaglandin E (PGE) receptor subtype EP4 antagonist on bone metastasis of cancer to clarify PGE’s role in bone metastasis. Metastatic regions were detected in femurs accompanying severe bone loss in mice injected with B