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Autor:
Matthias Blüher, Mathias Fasshauer, Anne-Marie Chambaut-Guérin, Johannes Klein, Ralf Paschke, Ulrike Lossner, Margit Klier, Susan Kralisch
Publikováno v:
FEBS Letters. 560:153-157
Tumor necrosis factor (TNF) alpha-induced adipose-related protein (TIARP) is a novel TNFalpha-stimulated protein in adipocytes. Besides TNFalpha, interleukin (IL)-6 has recently been shown to be another adipocytokine implicated in insulin resistance.
Autor:
Hiroshi Maegawa, Junko Okano, Tomoya Terashima, Lawrence Chan, Yuki Nakae, Hiroshi Urabe, Miwako Katagi, Kazuhiro Matsumura, Hideto Kojima, Nobuhiro Ogawa, Jun Udagawa
Publikováno v:
FEBS letters. 588(6)
Diabetic peripheral neuropathy is a major chronic diabetic complication. We have previously shown that in type 1 diabetic streptozotocin-treated mice, insulin- and TNF-α co-expressing bone marrow-derived cells (BMDCs) induced by hyperglycemia travel
Publikováno v:
FEBS Letters. 463:110-114
We demonstrated that adrenomedullin (AM) inhibited interleukin-1beta-induced tumor necrosis factor-alpha (TNF-alpha) secretion and gene transcription in Swiss 3T3 fibroblasts maximally to 23% and 18% of control, while the other peptides elevating int
Autor:
Licio A. Velloso, Juliana C. Moraes, Talita Romanatto, Paty K. Picardi, Silvana Chiavegatto, Marcela Bermúdez-Echeverry, Vivian C. Calegari, Maria Esméria Corezola do Amaral, Mario J.A. Saad
Publikováno v:
FEBS letters. 580(19)
TNF-alpha acts on the hypothalamus modulating food intake and energy expenditure through mechanisms incompletely elucidated. Here, we explore the hypothesis that, to modulate insulin-induced anorexigenic signaling in hypothalamus, TNF-alpha requires
Autor:
Chaya Brodie
Publikováno v:
FEBS letters. 394(2)
During the course of brain injury and inflammation there is an increased secretion of neurotrophic substances by astrocytes. We have examined the effect of the Th2-derived cytokine IL-10 and the Th1-derived cytokines Il-2 and IFN-gamma on the secreti
Autor:
Shoji Iwasaki, Masafumi Tsujimoto, Michiaki Kohno, Akira Hattori, Katsuhito Murase, Masahiro Sato, Kyozo Hayashi
Publikováno v:
FEBS letters. 340(3)
A possible interaction between tumor necrosis factor-alpha (TNF) and other cytokines/growth factors in stimulating the production of nerve growth factor (NGF) in Swiss 3T3 cells was studied. TNF's stimulatory activity on fibroblast NGF production was
Autor:
Yoichi Oikawa, N. Uozumi, Eiji Yamato, Akira Shimada, Takao Shimizu, Mayu Yamamoto, Fumi Tashiro, Jun-ichi Miyazaki
Publikováno v:
FEBS Letters. (18):3975-3978
Cytosolic phospholipase A(2)alpha (cPLA(2)alpha) plays an important role in arachidonate pathway. To investigate the contribution of cPLA(2)alpha to autoimmune diabetes, we established non-obese diabetic (NOD) mouse, an excellent model for human type
Autor:
Hiromasa Kobayashi, Yoshikatsu Nakai, Hajime Segawa, Hiroo Imura, Mitsuo Fukushima, Tomoko Tominaga, Osamu Ebisui, Junichi Fukata, Norihiko Murakami
Publikováno v:
FEBS Letters. (1):100-104
To study the cellular mechanisms of interleukin-1 (IL-1) in the pituitary corticotroph, we studied the properties of IL-1 receptors on a mouse pituitary ACTH-producing cell line, AtT-20. Scatchard plot analysis revealed a single type of receptor with
Autor:
Rina Yu, In-Seob Han, Tohru Fushiki, Nobuyuki Takahashi, Tsuyoshi Goto, Jun-Young Park, Teruo Kawada, Tadao Kurata, Byung-Sam Kim
Publikováno v:
FEBS Letters. (1-3):266-270
Capsaicin, a major ingredient of hot pepper, is considered to exhibit anti-inflammatory properties. Our previous study demonstrated that capsaicin inhibited the production of pro-inflammatory mediators through NF-kappaB inactivation in LPS-stimulated
Publikováno v:
FEBS Letters. (1-2):41-45
Tumor necrosis factor (TNF) plays a central role in the state of insulin resistance leading to type II diabetes. We here describe the crosstalk of TNF with insulin signaling cascades in the mouse muscle cell line pmi28. TNF downregulated insulin indu