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Myometrial maxi-K channel β1 subunit modulation during pregnancy and after 17β-estradiol stimulation
Publikováno v:
FEBS Letters. 524:97-102
Myometrial maxi-K channels are modulated by beta subunits. We aimed to determine whether beta subunits are modulated to affect uterine excitability during gestation. RNase protection analyses revealed that mouse beta1 subunit transcripts are regulate
Autor:
Richard M. Denton, S. Kelly Moule
Publikováno v:
FEBS Letters. 439:287-290
Here we report that the β-adrenergic agonist isoproterenol increases the activity of the stress-activated kinase p38 MAPK over 10-fold in freshly isolated rat epididymal fat cells. Stimulation of the kinase was rapid, sustained for at least 60 min a
Autor:
Stefan Kahlert, M. Stimpel, Christian Grohé, Ludwig Neyses, Hans Vetter, K. Lobbert, Richard H. Karas
Publikováno v:
FEBS Letters. 416:107-112
Gender-based differences found in cardiovascular diseases raise the possibility that estrogen may have direct effects on cardiac tissue. Therefore we investigated whether cardiac myocytes and fibroblasts express functional estrogen receptors. Immunof
Autor:
Josef Houštěk, Ladislav Burýšek
Publikováno v:
FEBS Letters. 411:83-86
Mouse brown adipocytes in primary culture were shown to contain high levels of mRNA for interleukin-1alpha (IL-1alpha) which could be further stimulated up to 9-fold by norepinephrine (NE). Even higher stimulation by NE, up to 40-fold, was found in c
Publikováno v:
FEBS Letters. 391:117-120
In the present study, we describe a role for cyclic GMP (cGMP) in the signalling pathway that leads from alpha-adrenergic receptor activation to intracellular Ca2+ mobilization in rat lacrimal acinar cells. The alpha-adrenergic agonist, phenylephrine
Publikováno v:
FEBS Letters. 378:27-31
The TSH receptor (TSHR) and the LHCG receptor (LHR) are members of the family of G protein-coupled receptors. Recently, point mutations conferring constitutive activity to the TSHR and LHR have been observed as a cause of toxic adenoma and familial/s
Autor:
Horst Will, Ute Zacharias
Publikováno v:
FEBS Letters. 289:155-158
Porcine urine, unlike human urine, does not contain detectable amounts of urokinase-type plasminogen activator (u-PA). The plasminogen activator present in porcine urine is of tissue-type (t-PA) as identified by the following criteria. (1) Porcine ur
Publikováno v:
FEBS Letters. 261:67-70
Adenosine analogs, such as N6-cyclohexyladenosine (CHA) that are selective for A1-adenosine receptors, and analogs, such as 5'-N-ethylcarboxamidoadenosine (NECA) that are active at both A1 and A2 receptors, cause a profound depression of locomotor ac
Autor:
Ichiro Wakabayashi, Satoshi Matsusaka
Publikováno v:
FEBS letters. 579(30)
The purpose of the present study was to investigate whether 5-hydroxytryptamine (5-HT, serotonin) affects migration of vascular endothelial cells. 5-HT significantly enhanced migration of human aortic endothelial cells (HAECs), and this enhancement w
Publikováno v:
FEBS letters. 505(2)
Treatment of HepG2 cells with forskolin led to 60–100% stimulation of system A activity, measured as the Na+-dependent uptake of α-(methylamino)isobutyric acid. The stimulation was reproducible with cholera toxin and dibutyryl cAMP, and inhibitabl