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Autor:
Chen-Yu Zhang, Chang Liu, Chunni Zhang, Pingping Shen, Peixiang Zhang, Junfeng Zhang, Yan Zhang
Publikováno v:
FEBS Letters. 579:1446-1452
PGC-1alpha mRNA and protein are elevated in islets from multiple animal models of diabetes. Overexpression of PGC-1alpha impairs glucose-stimulated insulin secretion (GSIS). However, it is not well known which metabolic events lead to upregulation of
Autor:
Toshihiko Yada, Putra Santoso, Yoichi Ueta, Darambazar Gantulga, Kenju Shimomura, Yuichi Hiraoka, Kazuya Sakuma, Yuko Maejima, Shigeyasu Tanaka, Katsuhiko Nishimori, Kenichi Katsurada
Publikováno v:
FEBS letters. 588(23)
Intracerebroventricular injection of oxytocin (Oxt), a neuropeptide produced in hypothalamic paraventricular (PVN) and supraoptic nuclei (SON), melanocortin-dependently suppresses feeding. However, the underlying neuronal pathway is unclear. This stu
Autor:
Shoaib Chowdhury, Masaki Takiguchi, Katsuro Iwase, Seiichi Oyadomari, Motoaki Shichiri, Masataka Mori, Fumihiko Matsuno, Tatsuya Kimura, Eiichi Araki
Publikováno v:
FEBS Letters. 478:141-146
The gene for a transcription factor hepatocyte nuclear factor-4alpha (HNF-4alpha) is responsible for maturity-onset diabetes of the young, type 1. We examined hormonal regulation of the HNF-4alpha gene in the liver. Stimulation of primary-cultured ra
Autor:
Yumiko Urakami, Yukiya Hashimoto, Ken-ichi Inui, Nobuhiko Nakamura, Masahiro Okuda, Kazushige Takahashi, Hideyuki Saito
Publikováno v:
FEBS Letters. 461:339-342
The organic cation transporter (OCT) mediates translocation of various cationic molecules including drugs, toxins and endogenous substances. We examined gender differences in the expression of rat (r) OCT2 in the kidney. Slices and basolateral membra
Publikováno v:
FEBS Letters. 458:157-161
Induction of uncoupling protein (UCP) genes in adipose tissues from young and old rats exposed to cold was compared. UCP1 mRNA expression in brown adipose tissue (BAT) was enhanced in both young and old rats after cold exposure, but the expression wa
Publikováno v:
FEBS Letters. 449:273-276
The expression of the cellular protooncogene c-ski was examined in the rat uterus. In situ hybridization revealed that c-ski mRNA was expressed in the uterus of the adult rat on the day of estrous and localized mainly in the luminal and glandular epi
Publikováno v:
FEBS Letters. 371:324-328
ob gene regulation is as yet unknown. We first examined whether the ob gene is under physiological control by the nutritional state. Fasting produced a sharp (95%) decrease of ob mRNA in epididymal and inguinal fat pads from 24 h onward. Refeeding ra
Autor:
Noriaki Shimokawa, Masayoshi Yamaguchi
Publikováno v:
FEBS Letters. 316:79-84
The effect of signal transduction-related factors was investigated to clarify the expression mechanism for mRNA of the hepatic Ca(2+)-binding protein regucalcin in the liver of rats. The change of regucalcin mRNA levels was analyzed by Northern blott
Publikováno v:
FEBS Letters 581 (2007) 29
FEBS Letters, 581(29), 5617-5626
FEBS Letters, 581(29), 5617-5626
A tight hormonal control of energy homeostasis is of pivotal relevance for animals. Recent evidence suggests an involvement of the nuclear receptor NR1i3 (CAR). Fasting induces CAR by largely unknown mechanisms and CAR-deficient mice are defective in
Publikováno v:
FEBS letters. 530(1-3)
Although resistin has been thought to be an important link between obesity and diabetes, recent results do not support this hypothesis. We speculated that resistin may be involved in inflammatory processes and be induced by inflammatory stimuli. In t