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Autor:
Chen-Yu Zhang, Chang Liu, Chunni Zhang, Pingping Shen, Peixiang Zhang, Junfeng Zhang, Yan Zhang
Publikováno v:
FEBS Letters. 579:1446-1452
PGC-1alpha mRNA and protein are elevated in islets from multiple animal models of diabetes. Overexpression of PGC-1alpha impairs glucose-stimulated insulin secretion (GSIS). However, it is not well known which metabolic events lead to upregulation of
Autor:
Shoaib Chowdhury, Masaki Takiguchi, Katsuro Iwase, Seiichi Oyadomari, Motoaki Shichiri, Masataka Mori, Fumihiko Matsuno, Tatsuya Kimura, Eiichi Araki
Publikováno v:
FEBS Letters. 478:141-146
The gene for a transcription factor hepatocyte nuclear factor-4alpha (HNF-4alpha) is responsible for maturity-onset diabetes of the young, type 1. We examined hormonal regulation of the HNF-4alpha gene in the liver. Stimulation of primary-cultured ra
Publikováno v:
FEBS Letters. 458:157-161
Induction of uncoupling protein (UCP) genes in adipose tissues from young and old rats exposed to cold was compared. UCP1 mRNA expression in brown adipose tissue (BAT) was enhanced in both young and old rats after cold exposure, but the expression wa
Publikováno v:
FEBS Letters. 371:324-328
ob gene regulation is as yet unknown. We first examined whether the ob gene is under physiological control by the nutritional state. Fasting produced a sharp (95%) decrease of ob mRNA in epididymal and inguinal fat pads from 24 h onward. Refeeding ra
Autor:
Noriaki Shimokawa, Masayoshi Yamaguchi
Publikováno v:
FEBS Letters. 316:79-84
The effect of signal transduction-related factors was investigated to clarify the expression mechanism for mRNA of the hepatic Ca(2+)-binding protein regucalcin in the liver of rats. The change of regucalcin mRNA levels was analyzed by Northern blott
Publikováno v:
FEBS letters. 530(1-3)
Although resistin has been thought to be an important link between obesity and diabetes, recent results do not support this hypothesis. We speculated that resistin may be involved in inflammatory processes and be induced by inflammatory stimuli. In t
Autor:
H. Wang, C. Minkin, W.R. Holloway, F.McL. Collier, Mary Malakellis, Damian E. Myers, Geoffrey C. Nicholson
Publikováno v:
FEBS letters. 463(3)
Although the important roles of RANK/RANKL in osteoclastogenesis have been established, their roles in the regulation of mature osteoclasts remain uncertain. Microisolation has been used to obtain pure populations of rat and human osteoclasts for RT-
Autor:
Mamoru Kurokawa, Tetsuya Kakuma, Toshiie Sakata, Takayuki Masaki, Shuji Hidaka, Hironobu Yoshimatsu
Publikováno v:
FEBS letters. 418(3)
Evidence is rapidly emerging which suggests that uncoupling protein 2 (UCP2), by virtue of its ubiquitous expression, may be important for determining basal metabolic rate. To assess the functional modulation of UCP2 gene expression in relation to bo
Publikováno v:
FEBS letters. 382(1-2)
We have used mRNA differential display to isolate genes that are induced by neural activity in rat hippocampus. One of these encodes activin beta A subunit. Convulsive seizure caused by kainate significantly induced the expression of activin beta A m
Autor:
Shigeyasu Tanaka, Yoshito Ibuki, Kaoru Miyamoto, Yoshio Ohyama, Satoshi Karino, Mari Tano, Takashi Minegishi, Kazuto Nakamura
Publikováno v:
FEBS letters. 362(2)
In a previous experiment, it was shown that midkine (MK) was quite abundant in the follicular fluid; the concentration of MK in bovine follicular fluid was estimated to be 125 μg/l. To investigate the regulation of MK production in the ovary, we exa