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Autor:
Richard M. Denton, S. Kelly Moule
Publikováno v:
FEBS Letters. 439:287-290
Here we report that the β-adrenergic agonist isoproterenol increases the activity of the stress-activated kinase p38 MAPK over 10-fold in freshly isolated rat epididymal fat cells. Stimulation of the kinase was rapid, sustained for at least 60 min a
Publikováno v:
FEBS Letters. 378:27-31
The TSH receptor (TSHR) and the LHCG receptor (LHR) are members of the family of G protein-coupled receptors. Recently, point mutations conferring constitutive activity to the TSHR and LHR have been observed as a cause of toxic adenoma and familial/s
Publikováno v:
FEBS letters. 505(2)
Treatment of HepG2 cells with forskolin led to 60–100% stimulation of system A activity, measured as the Na+-dependent uptake of α-(methylamino)isobutyric acid. The stimulation was reproducible with cholera toxin and dibutyryl cAMP, and inhibitabl
Publikováno v:
FEBS Letters. (2-3):242-246
Hemin stimulates cAMP production in human peripheral blood mononuclear cells (PBMC). The kinetics are similar to that of hormone-induced cAMP generation, namely a rapid effect followed by a desensitization phase. Several experimental findings suggest
Publikováno v:
FEBS Letters. (1):13-16
The beta-adrenergic agonist isoproterenol stimulates inositol trisphosphate (IP3) formation and cytosolic Ca2+ [( Ca2+]i) mobilization in rat parotid acini via a cAMP-dependent process. Atropine, a muscarinic antagonist, inhibited these isoproterenol
Publikováno v:
FEBS letters. 184(1)
We have studied in rat Leydig cells, the effect of sub-active concentrations of porcine LH on the subsequent stimulation of the cAMP and testosterone production by a sub-maximal concentration of pLH or hCG. We found that extremely low concentrations