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Autor:
Hideyuki Suzuki, Takafumi Mizushige, Hayato Aoki, Ryuhei Kanamoto, Kousaku Ohinata, Hiroshi Iwakura, Masaru Sato, Junya Nakato
Publikováno v:
FEBS Letters. 591:2121-2130
Ghrelin, an endogenous peptide isolated from the stomach, is known to stimulate food intake after peripheral administration. We found that the enzymatic digest of β-lactoglobulin decreases ghrelin secretion from the ghrelin-producing cell line MGN3-
Publikováno v:
FEBS Letters. 591:954-961
Cyclic GMP-AMP synthase (cGAS) is a DNA-sensing enzyme in the innate immune system. Recent studies using core-cGAS lacking the N terminus investigated the mechanism for binding of double-stranded (ds) DNA and synthesis of 2',3'-cyclic GMP-AMP (cGAMP)
Publikováno v:
FEBS letters. 593(12)
The transcription factor FOXO1 is considered to play roles in the regulation of energy metabolism in various tissues. To determine the metabolic changes occurring due to FOXO1 activation, we analyzed the metabolic profile of C2C12 myoblasts expressin
Publikováno v:
FEBS Letters. 590:1614-1629
Here, we investigate the mechanism through which paraoxonase 1 (PON1) may regulate cholesterol efflux. Pretreatment of oxLDL with PON1 (oxLDL-PON1) contributed to the formation of LysoPC. In J774 macrophages, oxLDL-PON1 increased cholesterol efflux b
Autor:
Chuan Li, Tetsuya Fukui, Shinya Hasegawa, Daiki Inoue, Masahiko Imai, Noriko Takahashi, Masahiro Yamasaki
Publikováno v:
FEBS Letters. 590:1592-1601
Acetoacetyl-CoA synthetase (AACS) is a ketone body-utilizing enzyme and is responsible for the synthesis of cholesterol and fatty acids. We have previously shown that AACS is cleaved by legumain, a lysosomal asparaginyl endopeptidase. In this study,
Autor:
Khoa N. Pham, Jaroslava Miksovska
Publikováno v:
FEBS Letters. 590:1114-1122
Interactions between downstream regulatory element antagonist modulator (DREAM) and presenilin 1 (PS1) are related to numerous neuronal processes. We demonstrate that association of PS1 carboxyl peptide (residues 445-467, HL9) with DREAM is calcium d
Autor:
Joost J. F. P. Luiken, Arend Bonen, Jan F. C. Glatz, Laelie A. Snook, Graham P. Holloway, Swati S. Jain, Xiao-Xia Han
Publikováno v:
Febs Letters, 589(19), 2769-2775. Elsevier
Muscle contains various fatty acid transporters (CD36, FABPpm, FATP1, FATP4). Physiological stimuli (insulin, contraction) induce the translocation of all four transporters to the sarcolemma to enhance fatty acid uptake similarly to glucose uptake st
Autor:
Norito Tamura, Noboru Mizushima, Yuriko Sakamaki, Ikuko Koyama-Honda, Hayashi Yamamoto, Taki Nishimura
Publikováno v:
FEBS letters. 591(23)
ATG2 is one of the autophagy-related (ATG) proteins essential for autophagosome formation and localizes to isolation membranes and lipid droplets in mammalian cells. Here, we investigated the requirement of regions in ATG2A for its organellar localiz
Publikováno v:
FEBS Letters. 588:3427-3434
The present study explored the involvement of miR-302a in adipocyte differentiation via interaction with 3′-untranslated region of peroxisome proliferator-activated receptor gamma (PPARγ) mRNA. In differentiating 3T3-L1 adipocytes, expression of m
Autor:
Dong-qun Liu, Shuai Lu, Yang-xin Zhang, Mei Ji, Shao-wei Wang, Rui-tian Liu, Weiyun Wang, Ling-xiao Zhang
Publikováno v:
FEBS letters. 591(21)
Beta-amyloid (Aβ) oligomers are strongly associated with the cascade of harmful events leading to neurodegeneration in Alzheimer's disease (AD). Elimination of Aβ oligomers or inhibition of Aβ assembly is a valuable therapeutic approach for the tr