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Publikováno v:
FEBS Letters. 595:2493-2503
Nonalcoholic fatty liver disease (NAFLD) can lead to hepatocellular carcinoma (HCC). The level of the transcription factor SOX2 correlates with HCC progression, but its role in fat accumulation remains unclear. Here, a high-fat diet, with and without
Autor:
Norihiro Tada, Yoko Fujiwara, Hyeon-Cheol Lee-Okada, Eri Nakamura, Ikuyo Ichi, Takehiko Yokomizo, Yuri Hayashi
Publikováno v:
FEBS Letters. 595:1920-1932
Deficiency of polyunsaturated fatty acids (PUFAs) is known to induce hepatic steatosis. However, it is not clearly understood which type of PUFA is responsible for the worsening of steatosis. This study observed a marked accumulation of hepatic triac
Autor:
Marios P. Stavridis, Mehmet Gundogdu, Sergio G. Bartual, Daan M. F. van Aalten, Andrew T. Ferenbach, Riina Žordania, Katrin Õunap, Veronica M. Pravata, Monica H. Wojcik, Sander Pajusalu
Publikováno v:
Febs Letters
'FEBS Letters ', vol: 594, pages: 717-727 (2020)
'FEBS Letters ', vol: 594, pages: 717-727 (2020)
X‐linked intellectual disabilities (XLID) are common developmental disorders. The enzyme O‐GlcNAc transferase encoded by OGT, a recently discovered XLID gene, attaches O‐GlcNAc to nuclear and cytoplasmic proteins. As few missense mutations have
Autor:
Naoyuki Taniguchi, Yasuhiko Kizuka, Hiromasa Inoue, Yoichiro Harada, Hirokazu Yagi, Ikuro Maruyama, Yuko Tokoro, Koichi Kato, Kiyotaka Kondo
Publikováno v:
Febs Letters
We investigated the correlation between metastatic behaviors of tumor cells and asparagine-linked glycosylation (N-glycosylation) of tumor-derived extracellular vesicles (EVs). Three mouse melanoma B16 variants with distinct metastatic potentials sho
Autor:
Mingming Xu, Jinyu Li, Peng Xu, Mingdong Huang, Peter A. Andreasen, Longguang Jiang, Yayu Chen
Publikováno v:
Xu, M, Chen, Y, Xu, P, Andreasen, P A, Jiang, L, Li, J & Huang, M 2018, ' Crystal structure of plasma kallikrein reveals the unusual flexibility of the S1 pocket triggered by Glu217 ', FEBS Letters, vol. 592, no. 15, pp. 2658-2667 . https://doi.org/10.1002/1873-3468.13191
Serine proteases play important roles in numerous physiological and pathophysiological processes. Moreover, serine proteases are classical subjects for studies of catalytic and inhibitory mechanisms of enzymes. Here, we determined the crystal structu
Autor:
Vladimir F. Lazarev, Pavel I. Semenyuk, Irina V. Guzhova, Dmitry V Sverchinsky, Boris A. Margulis, Vladimir A. Mitkevich
Publikováno v:
FEBS Letters. 591:4074-4082
Most Hsp70 chaperone inhibitors exert anti-cancer effects; however, their high cytotoxicity proposed the use of peptide fragments of the chaperone as safer modulators of its activity and as complements to customary drugs. One such peptide, ICit-2, wa
Autor:
Hideyuki Suzuki, Takafumi Mizushige, Hayato Aoki, Ryuhei Kanamoto, Kousaku Ohinata, Hiroshi Iwakura, Masaru Sato, Junya Nakato
Publikováno v:
FEBS Letters. 591:2121-2130
Ghrelin, an endogenous peptide isolated from the stomach, is known to stimulate food intake after peripheral administration. We found that the enzymatic digest of β-lactoglobulin decreases ghrelin secretion from the ghrelin-producing cell line MGN3-
Publikováno v:
FEBS Letters. 590:1614-1629
Here, we investigate the mechanism through which paraoxonase 1 (PON1) may regulate cholesterol efflux. Pretreatment of oxLDL with PON1 (oxLDL-PON1) contributed to the formation of LysoPC. In J774 macrophages, oxLDL-PON1 increased cholesterol efflux b
Autor:
Chuan Li, Tetsuya Fukui, Shinya Hasegawa, Daiki Inoue, Masahiko Imai, Noriko Takahashi, Masahiro Yamasaki
Publikováno v:
FEBS Letters. 590:1592-1601
Acetoacetyl-CoA synthetase (AACS) is a ketone body-utilizing enzyme and is responsible for the synthesis of cholesterol and fatty acids. We have previously shown that AACS is cleaved by legumain, a lysosomal asparaginyl endopeptidase. In this study,
Publikováno v:
FEBS Letters. 588:3427-3434
The present study explored the involvement of miR-302a in adipocyte differentiation via interaction with 3′-untranslated region of peroxisome proliferator-activated receptor gamma (PPARγ) mRNA. In differentiating 3T3-L1 adipocytes, expression of m