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Publikováno v:
FEBS Letters. 586:996-1003
A high fat diet (HFD) induces substantial cardiac metabolic alteration(s), but the initiating molecular events remain unclear. We assessed the early cardiac energy metabolic changes in C57/BJ mice fed a HFD for 10days. Carbohydrate oxidation was mark
Publikováno v:
FEBS Letters. 577:507-511
The natural cofactor of phenylalanine hydroxylase (PAH), tetrahydrobiopterin (BH4), regulates the enzyme activity as well as being essential in catalysis. BH4-responsive PAH deficiency is a variant of hyperphenylalaninemia or phenylketonuria (PKU) ca
Publikováno v:
FEBS Letters. 570:25-29
Lecithin cholesterol acyltransferase (LCAT) is a key enzyme in the metabolism of high density lipoprotein (HDL), which has been found inversely correlated with atherosclerosis. Adenovirus mediated overexpression of human LCAT (hLCAT) in hamsters resu
Autor:
Haruhiko Osawa, Takahiro Ogura, Naoto Kubota, Yan Tang, Tatsuya Nishimiya, Takashi Kadowaki, Hideichi Makino, Yasuo Terauchi, Hiroshi Onuma, Masaaki Ochi
Publikováno v:
FEBS Letters. 542:65-68
Phosphodiesterase 3B (PDE3B) gene expression is generally reduced in large adipocytes of obese, insulin-resistant mice. This reduced gene expression is restored by peroxisome proliferator-activated receptor (PPAR) gamma ligands accompanied by a reduc
Autor:
Linda L. Demer, Simon Mark Jackson
Publikováno v:
FEBS Letters. 471:119-124
The reduced bone mineral density (BMD) observed in osteoporosis results, in part, from reduced activity of bone-forming osteoblasts. We examined the effect of peroxisome proliferator-activated receptor (PPAR) activators on MC3T3-E1 preosteoblast matu
Publikováno v:
FEBS Letters. 446:218-222
The present study demonstrates, in both hybrid NG108-15 and mouse neuroblastoma N18TG2 cells, the presence and regulation of PDE5 mRNA during cell differentiation. PDE5 cDNA probes in Northern blot analysis recognize a approximately 9 kb transcript i
Publikováno v:
FEBS Letters. 353:62-66
Redox-based modulation plays a role in transcriptional control of gene expression. In the present study, we investigated the possible role of reactive oxygen species in the induction of interleukin-6 (IL-6) mRNA and in increases in NF kappa B binding
Publikováno v:
FEBS Letters. 313:23-26
The half-life of the F1-ATPase beta-subunit (F1-beta) mRNA in ATPase-poor brown adipose tissue (BAT) (t1/2 = 9.5 h) was found to be 3-7-fold shorter than in liver (t1/2 = 27 h) and heart (t1/2 = 63 h) of mice. When translated in reticulocyte lysate,
Publikováno v:
FEBS Letters. 267:85-88
Northern blot analysis demonstrated that the concentration of inositol 1,4,5-trisphosphate (IP3) receptor mRNA was greatest in cerebellar tissue. Moderate amounts of IP3 mRNA were present in brain tissue without cerebellum and tissue of the thymus, h
Autor:
Gaetano Leto, Maria Teresa Maggiorella, Rosaria Varì, Umberto Di Mario, Massimo D'Archivio, Fausto Titti, Claudio Giovannini, Massimo Sanchez, Beatrice Scazzocchio, Roberta Masella, Carmela Santangelo, Leonardo Sernicola
Publikováno v:
FEBS letters. 580(10)
The effects of oxidised LDL (oxLDL) on cell proliferation, apoptosis and hormone-induced differentiation have been evaluated for the first time in 3T3-L1 preadipocytes. Unlike control cells, oxLDL-treated preadipocytes showed a high proliferation rat