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Autor:
Vladimir F. Lazarev, Pavel I. Semenyuk, Irina V. Guzhova, Dmitry V Sverchinsky, Boris A. Margulis, Vladimir A. Mitkevich
Publikováno v:
FEBS Letters. 591:4074-4082
Most Hsp70 chaperone inhibitors exert anti-cancer effects; however, their high cytotoxicity proposed the use of peptide fragments of the chaperone as safer modulators of its activity and as complements to customary drugs. One such peptide, ICit-2, wa
Autor:
Hideyuki Suzuki, Takafumi Mizushige, Hayato Aoki, Ryuhei Kanamoto, Kousaku Ohinata, Hiroshi Iwakura, Masaru Sato, Junya Nakato
Publikováno v:
FEBS Letters. 591:2121-2130
Ghrelin, an endogenous peptide isolated from the stomach, is known to stimulate food intake after peripheral administration. We found that the enzymatic digest of β-lactoglobulin decreases ghrelin secretion from the ghrelin-producing cell line MGN3-
Autor:
Dong-qun Liu, Shuai Lu, Yang-xin Zhang, Mei Ji, Shao-wei Wang, Rui-tian Liu, Weiyun Wang, Ling-xiao Zhang
Publikováno v:
FEBS letters. 591(21)
Beta-amyloid (Aβ) oligomers are strongly associated with the cascade of harmful events leading to neurodegeneration in Alzheimer's disease (AD). Elimination of Aβ oligomers or inhibition of Aβ assembly is a valuable therapeutic approach for the tr
Autor:
Jean Christophe Marvaud, Yannik Pereira, Mahmood Tavallaie, Maryse Gibert, Maria Manich, Stéphanie Raffestin, Alexandre Chenal, Daniel Gillet, Michel R. Popoff
Publikováno v:
FEBS Letters. 572:299-306
The botulinum neurotoxin A C-terminal fragment (Hc), which mediates the binding of the toxin to neuronal cell surface receptors, comprises two subdomains, Hc-N (amino acids 873–1095) and Hc-C (amino acids 1096–1296). In order to define the minima
Autor:
J.-P Gallivan, Michael J. McGarvey
Publikováno v:
FEBS Letters. 554:485-488
NS3 proteins of flaviviruses contain motifs which indicate that they possess protease and helicase activities. The helicases are members of the DExD/H box helicase superfamily and NS3 proteins from some flaviviruses have been shown to possess ATPase
Autor:
Viktor Magdolen, Sumito Sato, Achim Krüger, Horst Kessler, Wolfgang A. Schmalix, Bernd Muehlenweg, Manfred Schmitt, Charlotte Kopitz
Publikováno v:
FEBS Letters. 528:212-216
Urokinase-type plasminogen activator (uPA) binds with high affinity to its specific cell surface receptor (uPAR) (CD87) via a well-defined sequence within the N-terminal region of uPA (uPA(19-31)). Since this uPA/uPAR-interaction plays a significant
Publikováno v:
FEBS Letters. 481:261-265
The insulin-responsive glucose transporter, Glut4, exhibits a unique subcellular distribution such that in the absence of insulin >95% of the protein is stored within intracellular membranes. In response to insulin, Glut4 exhibits a large mobilisatio
Autor:
Monica Garcia, Rosa M. Pintó, Juan F. González-Dankaart, Albert Bosch, Gloria Sánchez, Isabel Haro, Susana Guix, M. José Gómara
Publikováno v:
FEBS Letters. 438:106-110
The immune responses elicited in mice by different forms of the VP3(110–121) B-epitope of the hepatitis A virus (HAV) were studied. Different forms of incorporation in liposomes were tested, encapsulation, rather than surface exposure, being the be
Autor:
Julio A. Camarero, Esteban Domingo, David Andreu, Jordi J. Cairó, Ernest Giralt, Mauricio G. Mateu
Publikováno v:
FEBS Letters. 328:159-164
A cyclic disulfide peptide representing antigenic site A of foot-and-mouth-disease virus (FMDV) strain C-S8cl (residues 134 to 155 of viral protein l (VP1) with Tyr136 and Arg153 replaced by cystine; TTCTASARGDLAHLTTTHACHL) was synthesized by solid p
Publikováno v:
FEBS Letters. 268:291-295
The acidic 80 kDa protein kinase C (PKC) substrate was purified from 2.3 × 1010 Swiss 3T3 fibroblasts. Partial amino add sequence data were obtained from five peptides generated by S. aureus V8 cleavage of the protein, enabling a total of 91 amino a