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Autor:
Dong-qun Liu, Shuai Lu, Yang-xin Zhang, Mei Ji, Shao-wei Wang, Rui-tian Liu, Weiyun Wang, Ling-xiao Zhang
Publikováno v:
FEBS letters. 591(21)
Beta-amyloid (Aβ) oligomers are strongly associated with the cascade of harmful events leading to neurodegeneration in Alzheimer's disease (AD). Elimination of Aβ oligomers or inhibition of Aβ assembly is a valuable therapeutic approach for the tr
Publikováno v:
FEBS Letters. 502:46-52
The aim of this study was to investigate the molecular basis of human IgE–allergen interaction by screening a phage-displayed peptide library with an allergen-specific human IgE-mimicking monoclonal antibody (mAb). A mAb that reacted with major gra
Autor:
Michinori Tanaka, Masako Takikawa, Takao Taki, Dai Ishikawa, Koichi Ogino, Naoto Yamaguchi, Tomohiro Asai, Naoto Oku, Hironori Kikkawa
Publikováno v:
FEBS Letters. 466:381-384
GD1alpha ganglioside-replica peptides were recently isolated from a phage-displayed random pentadecapeptide library by assaying for inhibition of adhesion of RAW117-H10 lymphosarcoma cells to hepatic sinusoidal microvessel endothelial (HSE) cells. We
Publikováno v:
FEBS Letters. 441:20-24
A novel peptide technology to produce mimicking peptides of carbohydrate moiety (which we propose to name glyco-replica peptides) is a useful tool to elucidate the functions of glycoconjugate. Carbohydrate moiety of ganglioside GD1alpha functions as
Autor:
Takashi Kuwahara, Issei Tanaka, Akira Sugawara, Naohisa Tamura, Kei Tashiro, Masashi Mukoyama, Ken Ebihara, Yoshihiro Ogawa, S. Ozaki, Kazuwa Nakao, Tomohiro Aoki, Kiyoshi Mori
Publikováno v:
FEBS Letters. 417:371-374
Using the signal sequence trap method, we have cloned a novel 12-membrane-spanning transporter-like protein, termed renal-specific transporter (RST), from the mouse kidney. RST is a 553-amino-acid protein highly homologous to recently cloned organic
Publikováno v:
FEBS Letters. 353:62-66
Redox-based modulation plays a role in transcriptional control of gene expression. In the present study, we investigated the possible role of reactive oxygen species in the induction of interleukin-6 (IL-6) mRNA and in increases in NF kappa B binding
Publikováno v:
FEBS Letters. 327:103-107
Leishmania mexicana amastigotes express a lysosomal protein, which is antigenically related to the promastigote surface metalloproteinase (gp63). It is shown that the purified gp63-related protein from amastigote is also an active metalloproteinase.
Publikováno v:
FEBS Letters. 313:23-26
The half-life of the F1-ATPase beta-subunit (F1-beta) mRNA in ATPase-poor brown adipose tissue (BAT) (t1/2 = 9.5 h) was found to be 3-7-fold shorter than in liver (t1/2 = 27 h) and heart (t1/2 = 63 h) of mice. When translated in reticulocyte lysate,
Publikováno v:
FEBS Letters. 309:37-40
The process of peroxisome proliferation in rodent liver by hypolipidemic compounds and related substances has recently been shown to be receptor-madiated. In the present study, we have examined the effect of oral administration of the strong peroxiso
Autor:
Ryohei Katoh, Hideoki Ogawa, Atsuhito Nakao, Yuko Ohnuma, Ko Okumura, Yuki Nakamura, Naomi Shimokawa, Masanori Miyata
Publikováno v:
FEBS letters. 583(12)
A major house dust mite allergen Der f 1 belongs to the papain-like cysteine protease family. This study investigated whether Der f 1 can cleave the latency-associated peptide (LAP) of transforming growth factor (TGF)-beta via its proteolytic activit