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Publikováno v:
FEBS Letters. 595:2493-2503
Nonalcoholic fatty liver disease (NAFLD) can lead to hepatocellular carcinoma (HCC). The level of the transcription factor SOX2 correlates with HCC progression, but its role in fat accumulation remains unclear. Here, a high-fat diet, with and without
Autor:
Norihiro Tada, Yoko Fujiwara, Hyeon-Cheol Lee-Okada, Eri Nakamura, Ikuyo Ichi, Takehiko Yokomizo, Yuri Hayashi
Publikováno v:
FEBS Letters. 595:1920-1932
Deficiency of polyunsaturated fatty acids (PUFAs) is known to induce hepatic steatosis. However, it is not clearly understood which type of PUFA is responsible for the worsening of steatosis. This study observed a marked accumulation of hepatic triac
Autor:
Hideyuki Suzuki, Takafumi Mizushige, Hayato Aoki, Ryuhei Kanamoto, Kousaku Ohinata, Hiroshi Iwakura, Masaru Sato, Junya Nakato
Publikováno v:
FEBS Letters. 591:2121-2130
Ghrelin, an endogenous peptide isolated from the stomach, is known to stimulate food intake after peripheral administration. We found that the enzymatic digest of β-lactoglobulin decreases ghrelin secretion from the ghrelin-producing cell line MGN3-
Publikováno v:
FEBS Letters. 590:1614-1629
Here, we investigate the mechanism through which paraoxonase 1 (PON1) may regulate cholesterol efflux. Pretreatment of oxLDL with PON1 (oxLDL-PON1) contributed to the formation of LysoPC. In J774 macrophages, oxLDL-PON1 increased cholesterol efflux b
Publikováno v:
FEBS Letters. 588:3427-3434
The present study explored the involvement of miR-302a in adipocyte differentiation via interaction with 3′-untranslated region of peroxisome proliferator-activated receptor gamma (PPARγ) mRNA. In differentiating 3T3-L1 adipocytes, expression of m
Autor:
Jing-Yu Leng, Zhirong Zhang, Yi-Juan Zhang, Ming Li, Ai-Guo Sha, Wenbo Deng, Fei Gao, Xiu Xu, Zeng-Ming Yang, Zhen-Ao Zhao, Xiao-Huan Liang
Publikováno v:
FEBS Letters. 588:1580-1589
Glutathione peroxidase 3 (GPX3) is an important member of antioxidant enzymes for reducing reactive oxygen species and maintaining the oxygen balance. Gpx3 mRNA is strongly expressed in decidual cells from days 5 to 8 of pregnancy. After pregnant mic
Publikováno v:
FEBS Letters. 586:996-1003
A high fat diet (HFD) induces substantial cardiac metabolic alteration(s), but the initiating molecular events remain unclear. We assessed the early cardiac energy metabolic changes in C57/BJ mice fed a HFD for 10days. Carbohydrate oxidation was mark
Autor:
Ming-Da Wen, Liangyuan Li, Chang Liu, Cai-Hua Yuan, Da-Chuan Dong, Tao Jin, Zhao Zhang, Pengyu Gu, Xiang Gao
Publikováno v:
FEBS letters. 589(23)
Our understanding of how metabolic switches occur in the failing heart is still limited. Here, we report the emblematic pattern of metabolic alternations in two different mouse models. PP2Acα deficient hearts exhibited a dramatic decrease in the lev
Autor:
Philippe Valet, Angelo Parini, Atul Pathak, Oksana Kunduzova, Céline Guilbeau-Frugier, Denis Calise, Camille Foussal, Olivier Lairez
Publikováno v:
FEBS Letters
FEBS Letters, 2010, 584 (11), pp.2363-70. ⟨10.1016/j.febslet.2010.04.025⟩
FEBS Letters, 2010, 584 (11), pp.2363-70. ⟨10.1016/j.febslet.2010.04.025⟩
International audience; Adipose tissue secretes a variety of bioactive factors, which can regulate cardiomyocyte hypertrophy via reactive oxygen species (ROS). In the present study we investigated whether apelin affects ROS-dependent cardiac hypertro
Autor:
Consuelo Borrás, Juan Gambini, Jose Viña, Alexander A. Boldyrev, Tatiana N. Fedorova, Sergey Stvolinsky, Raúl López-Grueso
Publikováno v:
FEBS Letters. 583:2287-2293
The validity of the free radical theory of aging has been recently questioned. Our aim was to test whether there is oxidative stress in tissues critically involved in accelerated aging (senescence-accelerated mice, SAM) and whether this correlates wi