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Autor:
Yutaka Tamura, Akiko Suganami, Hiromichi Fujino, Keijo Fukushima, John W. Regan, Yuta Masuda, Suzu Endo, Toshihiko Murayama, Yumi Araki
Publikováno v:
FEBS Letters. 591:3771-3780
The 2-series of prostaglandin E (PGE2) is regarded as a pro-cancer prostanoid, whereas the 1- and 3-series (PGE1 and PGE3) are considered to act as anti-cancer prostanoids. We herein provide possible reasons why PGE1 and PGE3, but not PGE2, exert ant
Autor:
Meng-Long Zhao, Mei-Nan Yao, Xiao-Huan Liang, Hai-Tin Dou, Wenbo Deng, Yue-Fang Liu, Shu-Yun Li, Zeng-Ming Yang, Jie Liu
Publikováno v:
FEBS Letters. 590:2594-2602
Lipocalin-2 (Lcn2) is a small glycoprotein involved in a number of biological processes such as inflammation and antibacterial response. In our study, Lcn2 is expressed in the subluminal stromal cells at implantation site on day 5 of pregnancy. The e
Publikováno v:
FEBS Letters. 590:1614-1629
Here, we investigate the mechanism through which paraoxonase 1 (PON1) may regulate cholesterol efflux. Pretreatment of oxLDL with PON1 (oxLDL-PON1) contributed to the formation of LysoPC. In J774 macrophages, oxLDL-PON1 increased cholesterol efflux b
Autor:
Linqiang Li, Jiancheng Yang, Leigh Darryl Quarles, Gwendalyn D. King, Xiaobin Han, Zhousheng Xiao
Publikováno v:
FEBS Letters. 590:53-67
Mechanisms underlying the association between fibroblastic growth factor 23 (FGF-23) and inflammation are uncertain. We found that FGF-23 was markedly up-regulated in LPS/INF-γ-induced proinflammatory M1 macrophages and Hyp mouse-derived peritoneal
Autor:
Takanobu Taniguchi, Susanne M. Krug, Michael Fromm, Rafiqul Islam Khan, Yuichi Suzuki, Hatsumi Yoshiki, Tariqul Islam, Ikunobu Muramatsu, Shin-ichiro Karaki, Abu Syed Md Anisuzzaman, Atsukazu Kuwahara, Takashi Yazawa, Junsuke Uwada, Kiyonao Sada
Publikováno v:
FEBS Letters. 589:3640-3647
Impaired intestinal barrier function is one of the critical issues in inflammatory bowel diseases. The aim of this study is to investigate muscarinic cholinoceptor (mAChR)-mediated signaling for the amelioration of cytokine-induced barrier dysfunctio
Autor:
Harinder S. Hundal, Christopher Lipina
Publikováno v:
FEBS Letters. 589:3221-3227
Gangliosides constitute a large family of sialic acid-containing glycosphingolipids which play a key regulatory role in a diverse array of cellular processes, including receptor-associated signalling. Accordingly, the aberrant production of the gangl
Autor:
Melania E. Mercado-Pimentel, Mark A. Nelson, Benjamin C. Onyeagucha, Jana Jandova, Angel C. Pimentel, Qing V. Li
Publikováno v:
FEBS Letters. 589:2388-2393
S100P signaling through the receptor for advanced glycation end-products (RAGE) contributes to colon cancer invasion and metastasis, but the mechanistic features of this process are obscure. Here, we investigate whether activation of S100P/RAGE signa
Publikováno v:
FEBS Letters. 589:1225-1233
Glycosylation plays a significant role in determining the receptivity of the uterine endometrium to embryo. Fucosyltransferase IV (FUT4) is expressed stage-specifically in the uterine endometrium of mammalians, and considered as a marker of the endom
Autor:
Alejandra Gorostizaga, Mercedes Mori Sequeiros García, Carlos F. Mendez, Cristina Paz, Andrea Acquier
Publikováno v:
FEBS Letters. 587:3254-3260
Intrarenally-produced dopamine (DA) induces a large increase in urinary sodium excretion mainly due to the inhibition of tubular sodium reabsorption. We aimed to study the participation of reactive oxygen species (ROS) in DA signaling pathway in prox
Publikováno v:
FEBS letters
FEBS LETTERS
FEBS LETTERS
In this review, we discuss genetic evidence supporting Guyton’s hypothesis stating that blood pressure control is critically depending on fluid handling by the kidney. The review is focused on the genetic dissection of sodium and potassium transpor