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Publikováno v:
FEBS Letters. (16):3580-3586
Prolonged (12h) exposure of SH-SY5Y neuroblastoma cells to the mu-opioid receptor (MOPr) agonist [D-Ala(2),N-Me-Phe(4),Gly(5)-ol]-enkephalin (DAMGO) causes homologous desensitization as well as heterologous desensitization of the extracellular signal
Autor:
Keiko Yamauchi-Takihara, Shinji Negoro, Masahiro Izumi, Masanobu Funamoto, Ichiro Kawase, Yuichi Oshima, Yasushi Fujio, Yoshikazu Nakaoka, Hisao Hirota
Publikováno v:
FEBS Letters. (1-3):123-126
Aldosterone is thought to regulate cardiac work independently of sodium retention, though the mechanisms remain to be known. In the present study, we have demonstrated that aldosterone reinforces endothelin-mediated cardiac hypertrophy with the incre
Autor:
Zoltan Kiss, Wayne H. Anderson
Publikováno v:
FEBS Letters. (2):145-148
We have shown that in an estrogen receptor-negative multidrug-resistant subline of MCF-7 human breast carcinoma cells longer-term (24 h), but not shorter-term (30 min), treatments with clinically relevant (2-5 microM) concentrations of tamoxifen (TAM
Autor:
Francois Berthiaume, John A. Frangos
Publikováno v:
FEBS Letters. (3):277-279
Fluid flow and several other agonists induce prostacyclin (PGI2) production in endothelial cells, G proteins mediate the response of a large number of hormones such as histamine, but the transduction pathway of the flow signal is unclear. We found th
Autor:
Toshio Hirano, Akio Ando, Kenji Yokoyama, Megumu Fukunaga, Mari Fujibayashi, Satoshi Ochi, Naohiko Ueda, Takenobu Kamada, Yoshihiro Fujiwara
Publikováno v:
FEBS Letters. (2):265-267
Interleukin 6 (IL-6) is one of the potent autocrine growth factors for mesangial cells. We investigated the signal transduction mechanism or IL-6 in cultured rat mesangial cells. IL-6 induced a transient increase of inositol 1,4,5-trisphosphate (Ins
Publikováno v:
FEBS Letters. (1):78-80
Our aim was to observe whether normal human T-cells respond to mitogenic stimulation with large whole-cell inward currents (composed of identifiable single-channel contributions) when [Ca2+]i is not markedly lowered but instead kept normal or moderat
Publikováno v:
FEBS Letters. (1-2):24-26
Peroxisome proliferators and thyroid hormones have a number of common metabolic effects. The possibility that the signal transduction pathways of both groups of effectors converge at the receptor level was investigated. It was shown that T3, specific
Publikováno v:
FEBS letters. 249(2)
The effect of forskolin on cGMP regulation was investigated using dispersed rat pinealocytes. Forskolin stimulated cGMP accumulation in a concentration-dependent manner; this response was strongly potentiated by an α1-adrenergic → [Ca2+]i mechanis
Publikováno v:
FEBS letters. 195(1-2)
In guinea pig caudate slices preloaded with [3H]choline, superfusion with medium containing Ca2+ and the phorbol ester TPA (12-O-tetradecanoyl phorbol 13-acetate) produced an increase in the Ca2+-dependent, depolarization-evoked release of acetylchol
Autor:
M.Maureen Dale, Adrienne Penfield
Publikováno v:
FEBS letters. 185(1)
Indomethacin at a concentration (1O −4 M) which depressed the effect on O 2 − generation by fMet-Leu-Phe, markedly enhanced O 2 − , generation by both 1-oleoyl-2-acetylglycerol and the calcium ionophore, A23187. These results are explicable in