Zobrazeno 1 - 10
of 15
pro vyhledávání: ''
Autor:
Meng-Long Zhao, Mei-Nan Yao, Xiao-Huan Liang, Hai-Tin Dou, Wenbo Deng, Yue-Fang Liu, Shu-Yun Li, Zeng-Ming Yang, Jie Liu
Publikováno v:
FEBS Letters. 590:2594-2602
Lipocalin-2 (Lcn2) is a small glycoprotein involved in a number of biological processes such as inflammation and antibacterial response. In our study, Lcn2 is expressed in the subluminal stromal cells at implantation site on day 5 of pregnancy. The e
Autor:
Ali Zamani, Zhican Qu
Publikováno v:
FEBS Letters. 586:2360-2365
Serotonin, a known neurotransmitter, also functions as an angiokine to promote angiogenesis. The majority of serotonin in the human body is stored in platelets, and platelet aggregation leads to significant release of serotonin in thrombotic tumor en
Autor:
Shu Wang, Xiuqing Huang, Yingsheng Zhou, Lanfang Li, Yong Man, Jian Li, Qinghua He, Jianye Wang
Publikováno v:
FEBS Letters. 584:995-1000
TNF-alpha-induced insulin resistance is associated with generation of reactive oxygen species (ROS). This study aims at defining the link between ROS production and hepatic insulin resistance. Treatment with TNF-alpha increased ROS generation through
Publikováno v:
FEBS Letters. 583:3101-3106
Epinephrine inhibits insulin release by activation of K(+) channels and subsequent hyperpolarization of pancreatic beta cells. The present study explored whether epinephrine-induced hyperpolarization is modified by phosphatidylinositol 3-kinase (PI3K
AdipoR1 mediates the anorexigenic and insulin/leptin-like actions of adiponectin in the hypothalamus
Autor:
Bruno Geloneze, Licio A. Velloso, Mario J.A. Saad, Eliana P. Araújo, Andressa Coope, Marciane Milanski, Marcos Antonio Tambascia
Publikováno v:
FEBS Letters. 582:1471-1476
Adiponectin exerts an insulin-sensitizing effect, improving insulin action in peripheral tissues and restraining insulin resistance. Here, we explore the hypothesis that adiponectin can reproduce some of the actions of insulin/leptin in the hypothala
Publikováno v:
FEBS Letters. 581:5885-5890
Inhibition of the lipid phosphatase SH2-domain containing inositol phosphatase 2 (SHIP2) in L6-C10 muscle cells, in 3T3-L1 adipocytes and in the liver of db/db mice has been shown to ameliorate insulin signal transduction and established SHIP2 as a n
Autor:
Wenhua Zheng, Ruifang Li, Kang Le, Huijie Zhang, Peiqing Liu, Rongbiao Pi, Jie Gao, Ping Wang
Publikováno v:
FEBS Letters. 581:3311-3316
Activation of peroxisome proliferator-activated receptor-alpha (PPAR-alpha) has been recently reported to inhibit vascular inflammatory response and prevent cardiac hypertrophy. However, it is unclear how the activation of PPAR-alpha regulates hypert
Publikováno v:
FEBS Letters. 580:3211-3216
We here provide definitive evidence that ginsenoside-Rg1, the pharmacologically active component of ginseng, is a functional ligand of the glucocorticoid receptor (GR) as determined by fluorescence polarization assay. Rg1 increased the phosphorylatio
Publikováno v:
FEBS Letters. 573:175-180
Histamine and thrombin cause phosphorylation and activation of endothelial NO-synthase (eNOS) on Ser1177. We tested the role of various protein kinases in mediating this effect in human umbilical vein endothelial cells. Inhibition of the Ca2+/calmodu
Autor:
Shyam S. Chauhan, Ratnakar Singh, Saurabh Bharti, Dharamvir Singh Arya, Tajamul Hussain, Omar S. Al-Attas
Publikováno v:
FEBS letters. 586(2)
Herein, we studied the cross talk between 5-HT2B receptor blocker (SB-204741) and GSK-3β inhibitor (SB-216763) in isoproterenol-induced cardiac hypertrophy for 28days. SB-204741 treatment significantly ameliorated (P