Zobrazeno 1 - 10
of 428
pro vyhledávání: ''
Publikováno v:
FEBS Letters. 595:3042-3055
Selenium is an essential trace element of interest for its potential role in glucose homeostasis. The present study investigated the impact of selenium supplementation as selenomethionine (SeMet) on insulin secretion in MIN6-K8 cells, a pancreatic β
Publikováno v:
FEBS Letters. 595:2493-2503
Nonalcoholic fatty liver disease (NAFLD) can lead to hepatocellular carcinoma (HCC). The level of the transcription factor SOX2 correlates with HCC progression, but its role in fat accumulation remains unclear. Here, a high-fat diet, with and without
Autor:
Norihiro Tada, Yoko Fujiwara, Hyeon-Cheol Lee-Okada, Eri Nakamura, Ikuyo Ichi, Takehiko Yokomizo, Yuri Hayashi
Publikováno v:
FEBS Letters. 595:1920-1932
Deficiency of polyunsaturated fatty acids (PUFAs) is known to induce hepatic steatosis. However, it is not clearly understood which type of PUFA is responsible for the worsening of steatosis. This study observed a marked accumulation of hepatic triac
Publikováno v:
FEBS Letters. 595:1313-1321
The molecular mechanisms generating the mania-like abnormal behaviors caused by diacylglycerol (DG) kinase (DGK) η deficiency remain unclear. Here, we found that DGKη knockout markedly increased dopamine (DA) levels in the midbrain (DA-producing re
Autor:
Alexander Bartelt, Gökhan S. Hotamisligil, Martin D. Brand, Michael Schlame, Renata L.S. Goncalves
Publikováno v:
Febs Letters
Barth syndrome (BTHS) is a rare X-linked genetic disorder caused by mutations in the gene encoding the transacylase tafazzin and characterized by loss of cardiolipin and severe cardiomyopathy. Mitochondrial oxidants have been implicated in the cardio
Autor:
Liu Chengyu, Alan T. Remaley, Kasey C. Vickers, Kei‐ichiro Okuhira, Sten Braesch‐Andersen, Boris L. Vaisman, Maki Tsujita
Publikováno v:
FEBS Lett
Apolipoprotein (apo) A-I, the major structural protein of high-density lipoprotein (HDL), is present in human and mouse cerebrospinal fluid (CSF) despite its lack of expression in brain cells. To identify the origin of apoA-I in CSF, we generated int
Publikováno v:
FEBS Lett
Glycogen shortage during fasting coincides with dramatic changes in hepatic adenine nucleotide levels. The aim of this work was to study the relevance of liver glycogen in the regulation of the hepatic energy state during food deprivation. To this en
Autor:
Chao-Jun Li, Yue Zhao, Zheng Xing, Dandan Bu, Dan-Yang Chong, Jing Wu, Weiwei Tao, Bin Xue, Tong-Yu Zhang
Publikováno v:
FEBS Letters. 593:3054-3063
During the development of type 2 diabetes mellitus (T2DM), hyperinsulinemia is the earliest symptom. It is believed that long-term high insulin stimulation might facilitate insulin resistance in the liver, but the underlying mechanism remains unknown
Autor:
Ting Su, Dongyang Huang, Xina Xie, Bin Liang, Meihui Huang, Xuhong Song, Hongjin Liang, Xiaolan Chang
Publikováno v:
FEBS Letters. 593:1061-1071
Homocysteine (Hcy) is associated with nonalcoholic fatty liver disease (NAFLD). orphan nuclear receptor subfamily 4 group A member 1 (NR4A1) is involved in hepatic lipid metabolism. However, the potential role of NR4A1 in Hcy-associated NAFLD remains
Autor:
Denis, Raphaël, Busi, Florent, Castel, Julien, Morel, Chloé, Zhang, Wenchao, Bui, Linh-Chi, Sugamori, Kim, Prokopec, Stephenie, Boutros, Paul, Grant, Denis, Rodrigues-Lima, Fernando, Luquet, Serge, Dupret, Jean-Marie, Denis, Raphaël G.P., Bui, Linh‐Chi, Rodrigues‐Lima, Fernando, Dupret, Jean‐Marie
Publikováno v:
FEBS Letters
FEBS Letters, Wiley, 2019, 593 (8), pp.831-841. ⟨10.1002/1873-3468.13357⟩
FEBS Letters, Wiley, 2019, 593 (8), pp.831-841. ⟨10.1002/1873-3468.13357⟩
International audience; Recent studies have revealed a possible link between the activities of polymorphic arylamine N-acetyltransferases (NATs) and energy metabolism. We used a Nat1/Nat2 double knockout (KO) mouse model to demonstrate that ablation