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Publikováno v:
FEBS Letters. 590:1614-1629
Here, we investigate the mechanism through which paraoxonase 1 (PON1) may regulate cholesterol efflux. Pretreatment of oxLDL with PON1 (oxLDL-PON1) contributed to the formation of LysoPC. In J774 macrophages, oxLDL-PON1 increased cholesterol efflux b
Autor:
Chuan Li, Tetsuya Fukui, Shinya Hasegawa, Daiki Inoue, Masahiko Imai, Noriko Takahashi, Masahiro Yamasaki
Publikováno v:
FEBS Letters. 590:1592-1601
Acetoacetyl-CoA synthetase (AACS) is a ketone body-utilizing enzyme and is responsible for the synthesis of cholesterol and fatty acids. We have previously shown that AACS is cleaved by legumain, a lysosomal asparaginyl endopeptidase. In this study,
Autor:
Cesare Montecucco, Thomas Binz, Fulvio Bordin, Ornella Rossetto, Marco Pirazzini, Clifford C. Shone
Publikováno v:
FEBS Letters. 587:150-155
Tetanus and botulinum neurotoxins cause paralysis by cleaving SNARE proteins within the cytosol of nerve terminals. They are endocytosed inside acidic vesicles and the pH gradient across the membrane drives the translocation of their metalloprotease
Publikováno v:
FEBS Letters. 582:3893-3898
We have previously shown that homocysteine (Hcy) can induce monocyte chemoattractant protein-1 (MCP-1) secretion via reactive oxygen species (ROS) in human monocytes. Here, we show that Hcy upregulates expression of an important antioxidative protein
Autor:
John J.E. Haddad, Stephen C. Land
Publikováno v:
FEBS Letters. 505:269-274
A non-hypoxic, reactive oxygen species (ROS)-sensitive pathway mediating tumor necrosis factor-alpha (TNF-alpha)-dependent regulation of hypoxia-inducible factor-1alpha (HIF-alpha) was investigated in vitro. TNF-alpha mediated the translocation of HI
Autor:
Linda L. Demer, Simon Mark Jackson
Publikováno v:
FEBS Letters. 471:119-124
The reduced bone mineral density (BMD) observed in osteoporosis results, in part, from reduced activity of bone-forming osteoblasts. We examined the effect of peroxisome proliferator-activated receptor (PPAR) activators on MC3T3-E1 preosteoblast matu
Autor:
Dominique Pessayre, Bernard Fromenty, Ingrid Sauvage, Thomas Grandperret, Marie-Anne Robin, Veronique Descatoire
Publikováno v:
FEBS letters. 579(30)
Enhanced hepatic levels of cytochrome P450 2E1 (CYP2E1) may play a key role in the pathogenesis of some liver diseases because CYP2E1 represents a significant source of reactive oxygen species. Although a large fraction of CYP2E1 is located in the en
Publikováno v:
FEBS letters. 579(25)
The neurodegenerative disorder X-linked adrenoleukodystrophy (X-ALD) is caused by ABCD1 mutations and characterized by very long-chain fatty acid (VLCFA) accumulation. Cholesterol-lowering normalized VLCFA in fibroblasts and plasma of X-ALD patients.
Autor:
Kazuhiko Hora, Yuji Kamijo, Frank J. Gonzalez, Naoki Tanaka, Toshifumi Aoyama, Hideki Makishima, Kendo Kiyosawa
Publikováno v:
FEBS letters. 543(1-3)
Retinoid X receptor alpha (RXRalpha) can reveal diverse functions through forming a heterodimer with peroxisome proliferator-activated receptor alpha (PPARalpha). However, the mechanism of regulation of the cellular RXRalpha level is unclear. Thus, q
Autor:
Kyoichiro Higashi, Hiroshi Ogawara
Publikováno v:
FEBS letters. 267(1)
Regulation of phospholipase C (PLC) coupled with a G-protein was studied with Swiss 3T3 cells permeabilized by digitonin. In permeabilized cells, activation of phospholipase C required millimolar concentrations of ATP in addition to a G-protein activ