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Autor:
Valur Emilsson, Carolyn A. Lister, Michael A. Cawthorne, Jonathan R.S. Arch, Rolf P. de Groot
Publikováno v:
FEBS Letters. 455:170-174
Leptin concentrations are elevated in the majority of obese individuals raising the possibility that leptin resistance contributes to their obesity. Peripheral leptin administration for 48 h caused a several-fold increase in mRNA encoding the suppres
Autor:
Paola Bruni, Paola Nincheri, Marta Farnararo, Elena Rapizzi, Francesca Cencetti, Chiara Donati
Publikováno v:
FEBS letters. 581(23)
In this study, we report that low doses of tumor necrosis factor-alpha (TNFalpha) promote myogenesis in C2C12 myoblasts. Moreover, the cytokine increased sphingosine kinase (SphK) activity and induced SphK1 translocation to membranes. The inhibition
Publikováno v:
FEBS Letters. (3):263-265
The hepatic IL-6-receptor is composed of an 80 kDa IL-6-binding protein and a 130 kDa polypeptide (gp130) believed to be involved in signal transduction. Previous experiments have shown that the 80 kDa IL-6-receptor is up-regulated by glucocorticoids