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Autor:
Masayoshi Imagawa, Eri Yamada, Wataru Horinouchi, Shigehiro Osada, Natsuki Ochiai, Makoto Nishizuka
Publikováno v:
FEBS Letters. 590:4372-4380
KCNMA1 is a pore-forming α-subunit of the large conductance Ca2+ - and voltage-activated K+ channels, referred to as BK channels, which play key roles in various physiological functions. However, the role of KCNMA1 in mature adipocytes remains uncle
Autor:
Arup K. Indra, Stephen Hyter
Publikováno v:
FEBS Letters. 587:529-541
Skin homeostasis is maintained, in part, through regulation of gene expression orchestrated by type II nuclear hormone receptors in a cell and context specific manner. This group of transcriptional regulators is implicated in various cellular process
Autor:
Hiroyuki Miwa, Ayumi Miyake, Akihiko Shimada, Nobuyuki Itoh, Yoshiaki Nakayama, Yuki Yamashita, Yuya Kouta, Morichika Konishi, Hajime Yamauchi
Publikováno v:
FEBS Letters. 583:3643-3648
We identified a gene encoding a novel secreted protein in mice, humans, and zebrafish. As the protein of 222 amino acids is similar to Brorin, a secreted BMP antagonist, which is a member of the Chordin family, we named it Brorin-like. Recombinant Br
Autor:
Abu Asad Chowdhury, M. A. Mazid, Mitsuo Jisaka, Tsutomu Nagaya, Kohji Nishimura, Kohjiro Nagao, Kazushige Yokota
Publikováno v:
FEBS Letters. 580:6885-6890
15-Deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) has been identified as a natural ligand for peroxisome proliferator-activated receptor (PPAR) gamma to promote adipogenesis. However, it remains elusive about the ability of PPARgamma-expressing a
Autor:
Alessandra Castegna, Iolanda Spera, Vittoria Infantino, Alessio Menga, Erika M. Palmieri, Vito Iacobazzi
Publikováno v:
FEBS letters. 588(24)
The role of glutamine synthetase (GS) during adipocyte differentiation is unclear. Here, we assess the impact of GS on the adipocytic response to a proinflammatory challenge at different differentiation stages. GS expression at the late stages of dif
Autor:
Maike Streckert, Axel M. Gressner, Linda Bonzel, Marcin Stopa, Bert Delvoux, S Dooley, Peter ten Dijke
Publikováno v:
FEBS Letters. 502:4-10
To current knowledge, transforming growth factor beta (TGFbeta) signaling is mandatory to establish liver fibrosis and various molecular interventions designed to affect the TGFbeta system were successfully used to inhibit fibrogenesis. Activated hep
Publikováno v:
Bruedigam, C, Koedam, M, Chiba, H, Eijken, M & van Leeuwen, J P T M 2008, ' Evidence for multiple peroxisome proliferator-activated receptor gamma transcripts in bone : fine-tuning by hormonal regulation and mRNA stability ', FEBS Letters, vol. 582, no. 11, pp. 1618-24 . https://doi.org/10.1016/j.febslet.2008.04.012
FEBS Letters. Journal for the Rapid Publication of Short Reports in Biochemistry ....., 582(11), 1618-1624. Wiley-Blackwell
FEBS Letters. Journal for the Rapid Publication of Short Reports in Biochemistry ....., 582(11), 1618-1624. Wiley-Blackwell
The expression, regulation and functional significance of multiple peroxisome proliferator-activated receptor gamma transcript variants in bone were studied. PPARG transcripts giving rise to PPARg-1 protein were expressed in human osteoblasts, wherea
Autor:
Paola Bruni, Paola Nincheri, Marta Farnararo, Elena Rapizzi, Francesca Cencetti, Chiara Donati
Publikováno v:
FEBS letters. 581(23)
In this study, we report that low doses of tumor necrosis factor-alpha (TNFalpha) promote myogenesis in C2C12 myoblasts. Moreover, the cytokine increased sphingosine kinase (SphK) activity and induced SphK1 translocation to membranes. The inhibition
Publikováno v:
FEBS letters. 579(18)
In vivo and in vitro studies have suggested a neuroprotective role for Pituitary adenylate cyclase activating polypeptide (PACAP) against neuronal insults. Here, we showed that PACAP27 protects against neurotoxicity induced by rotenone, a mitochondri
Publikováno v:
FEBS letters. 492(1-2)
Liver development is regulated by soluble factors as well as cell–cell contacts. We previously reported that oncostatin M (OSM) induced hepatic maturation in a primary culture of embryonic day 14 liver cells. While OSM expression in the liver start