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Autor:
Guoliang Cui, Tilo Schlimbach, Sicong Ma, Jingxia Wu, Michael Schmitt, Agnes Hotz-Wagenblatt, Peter Angel, Kerstin Mohr
Publikováno v:
FEBS letters. 593(10)
To maintain immune tolerance, effector T-cell (Teff) responses must be checked by the regulatory T cells (Tregs) in time. It remains incompletely understood how Tregs sense real-time Teff activation. Here, we report that the AP-1 transcription factor
Publikováno v:
FEBS Letters. 587:826-832
The transcription factor Gli1 acts in the last known step of the Hedgehog signaling, and deregulation of Gli1 is implicated in human cancers. VHL protein is widely expressed in both fetal and adult tissues and acts as a tumor suppressor. Here, we dem
Publikováno v:
FEBS Letters. 581:5247-5254
ES cells can self-renew while preserving pluripotency and are able to differentiate into many cell types. In both processes, different signal transduction pathways are implicated, including the Wnt/beta-catenin pathway, which we here further analyzed
Autor:
Rakesh Kumar, Abhijit Mazumdar
Publikováno v:
FEBS Letters. 535:6-10
Stimulation of p21-activated kinase-1 (Pak1) and estradiol-estrogen receptor-α in mammary cancer cells promotes cell survival. We sought to determine whether estrogen stimulates the Pak1 pathway. We found that estrogen rapidly activated Pak1 kinase
Publikováno v:
FEBS letters. 588(5)
Hepatitis B virus X protein is a major factor in the HBV-induced disease developments. Stromal cell-derived factor-1 is a small cytokine that is strongly chemotactic for lymphocytes. We explored the role of HBx on recruitment of HBV-induced virus-non
Publikováno v:
FEBS letters. 555(2)
Our previous study has shown that lipophilic 3-hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitors of statins can inhibit interferon-gamma-induced inducible nitric oxide synthase gene expression in RAW264.7 macrophages. In this study, we showed
Publikováno v:
FEBS letters. 532(1-2)
Lymphotoxin-beta receptor (LTbetaR) is a member of the tumor necrosis factor receptor (TNFR) superfamily that activates nuclear factor-kappaB (NF-kappaB) through the IkappaB kinase (IKK) complex, the core of which is comprised of IKK1, IKK2 and NF-ka
Publikováno v:
FEBS Letters. (14):1913-1920
Polyubiquitylation leading to proteasomal degradation is a well-established mechanism for regulating TGF-β signal transduction components such as receptors and Smads. Recently, an equally important role was suggested for monoubiquitylation of both S
Publikováno v:
FEBS Letters. (2-3):132-136
Interleukin-10 (IL-10) has been used in the treatment of viral hepatitis in interferon-alpha (IFN-alpha) non-responders while patients who have high levels of IL-10 are poorly responsive to IFN-alpha. The mechanism underlying such controversial funct
Autor:
Yu-Cheng Zhang, Hui-Yan Li, Xue-Min Zhang, Ai-Ling Li, Sai-Sai Guo, Hai-Qing Tu, Yu-Bo Wang, Yan Chang, Wei-Hua Li, Rui Mu, Bo Tan, Xuan-He Qin, Min Wu, Tao Li
Publikováno v:
FEBS Letters. (19):2850-2858
Most of NF-κB (nuclear factor kappa B) signaling molecules have various types of post-translational modifications. In this study, we focused on ubiquitination and designed a siRNA library including most ubiquitin-binding domains. With this library,