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Publikováno v:
FEBS Letters. 585:2587-2591
Recently, we identified ganglioside GM2 activator protein (GM2AP) as a novel adipokine, and revealed that treatment of cultured cells with GM2AP impairs insulin signal transduction. The aim of this study was to examine the impact of GM2AP on glucose
Autor:
Byung-Sam Kim, Ha-Jung Kim, Hye-Sun Choi, Hong-Min Kim, Chu-Sook Kim, Choon-Soo Jeong, Rina Yu, Teruo Kawada
Publikováno v:
FEBS Letters. 585:2285-2290
HVEM is a member of the TNF receptor superfamily that plays a role in the development of various inflammatory diseases. In this study, we show that HVEM deficiency attenuates adipose tissue inflammatory responses and glucose intolerance in diet-induc
Autor:
Haruhiko Osawa, Takahiro Ogura, Naoto Kubota, Yan Tang, Tatsuya Nishimiya, Takashi Kadowaki, Hideichi Makino, Yasuo Terauchi, Hiroshi Onuma, Masaaki Ochi
Publikováno v:
FEBS Letters. 542:65-68
Phosphodiesterase 3B (PDE3B) gene expression is generally reduced in large adipocytes of obese, insulin-resistant mice. This reduced gene expression is restored by peroxisome proliferator-activated receptor (PPAR) gamma ligands accompanied by a reduc
Autor:
J Fernandez, Miguel Valdeolmillos
Publikováno v:
FEBS Letters. 477:33-36
Using microfluorescence in combination with image-analysis techniques we monitored intracellular calcium ([Ca(2+)](i)) dynamics in mouse islets of Langerhans loaded with fura-2 and recorded in vivo. [Ca(2+)](i) oscillates in the glycaemias range 5-10
Autor:
Hideki Katagiri, Junichi Miyazaki, Tomoichiro Asano, Koichi Ikuta, Fumi Tashiro, Yoshio Yazaki, Yoshitomo Oka, Hisamitsu Ishihara, Koichi Inukai, Masatoshi Kikuchi
Publikováno v:
FEBS Letters. 371:329-332
We have generated transgenic mice, in either C57BL/6 or C3H background, expressing antisense glucokinase mRNA in β-cells. The glucose phosphorylating activity at 60 mM glucose in transgenic islets was significantly lower than that in controls, and t
Autor:
Xiurong Rao, Shaona Niu, Zhenbo Huang, Guoqing Sheng, Hui Kong, Xiao-Jiang Li, Hao Wang, Chuan Yang, Jing Xu
Publikováno v:
FEBS letters. 585(1)
The function of the brainstem Hap1–Ahi1 complex in the regulation of feeding behavior was investigated. When mice were fasted or treated with 2-deoxy-d-glucose (2-DG), Hap1–Ahi1 was significantly upregulated. By using streptozotocin (STZ) to decr
Autor:
Sihong Song, Brant R. Burkhardt, Mark A. Atkinson, Mathew J. Parker, Clive Wasserfall, Y. Clare Zhang
Publikováno v:
FEBS letters. 579(25)
Insulin production afforded by hepatic gene therapy (HGT) retains promise as a potential treatment for type 1 diabetes, but successful approaches have been limited. We employed a novel and previously untested promoter for this purpose, glucose transp
Publikováno v:
FEBS letters. 311(3)
Hypoglycaemia is a major complication of severe malaria [(1990) Trans. Roy. Soc. Trop. Med. 84 (suppl. 2) 1–65], especially cerebral malaria, in which it is associated with increased mortality [(1990) Lancet 336, 1039–1043; (1989) Quart. J. Med.
Publikováno v:
FEBS Letters. 188:257-261
The uptake of 2-[1-14C]deoxyglucose in vivo by brown adipose tissue was greater than that of brain or heart in control mice on a whole tissue basis. When mice were treated with noradrenaline the rate of uptake of 2-[1-14C]deoxyglucose by brown adipos
Autor:
Pirrko Hirsimäki
Publikováno v:
FEBS Letters. 151:89-93
The possible similarities of the mechanism by which vinblastine induces autophagocytosis in liver were compared with the known effects of glucagon in glucagon-induced autophagocytosis. A single intraperitoneal injection of vinblastine produced a wave