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Publikováno v:
FEBS Letters. 595:2493-2503
Nonalcoholic fatty liver disease (NAFLD) can lead to hepatocellular carcinoma (HCC). The level of the transcription factor SOX2 correlates with HCC progression, but its role in fat accumulation remains unclear. Here, a high-fat diet, with and without
Autor:
Norihiro Tada, Yoko Fujiwara, Hyeon-Cheol Lee-Okada, Eri Nakamura, Ikuyo Ichi, Takehiko Yokomizo, Yuri Hayashi
Publikováno v:
FEBS Letters. 595:1920-1932
Deficiency of polyunsaturated fatty acids (PUFAs) is known to induce hepatic steatosis. However, it is not clearly understood which type of PUFA is responsible for the worsening of steatosis. This study observed a marked accumulation of hepatic triac
Publikováno v:
FEBS Letters. 595:1313-1321
The molecular mechanisms generating the mania-like abnormal behaviors caused by diacylglycerol (DG) kinase (DGK) η deficiency remain unclear. Here, we found that DGKη knockout markedly increased dopamine (DA) levels in the midbrain (DA-producing re
Autor:
Alexander Bartelt, Gökhan S. Hotamisligil, Martin D. Brand, Michael Schlame, Renata L.S. Goncalves
Publikováno v:
Febs Letters
Barth syndrome (BTHS) is a rare X-linked genetic disorder caused by mutations in the gene encoding the transacylase tafazzin and characterized by loss of cardiolipin and severe cardiomyopathy. Mitochondrial oxidants have been implicated in the cardio
Autor:
Liu Chengyu, Alan T. Remaley, Kasey C. Vickers, Kei‐ichiro Okuhira, Sten Braesch‐Andersen, Boris L. Vaisman, Maki Tsujita
Publikováno v:
FEBS Lett
Apolipoprotein (apo) A-I, the major structural protein of high-density lipoprotein (HDL), is present in human and mouse cerebrospinal fluid (CSF) despite its lack of expression in brain cells. To identify the origin of apoA-I in CSF, we generated int
Autor:
Chao-Jun Li, Yue Zhao, Zheng Xing, Dandan Bu, Dan-Yang Chong, Jing Wu, Weiwei Tao, Bin Xue, Tong-Yu Zhang
Publikováno v:
FEBS Letters. 593:3054-3063
During the development of type 2 diabetes mellitus (T2DM), hyperinsulinemia is the earliest symptom. It is believed that long-term high insulin stimulation might facilitate insulin resistance in the liver, but the underlying mechanism remains unknown
Autor:
Ting Su, Dongyang Huang, Xina Xie, Bin Liang, Meihui Huang, Xuhong Song, Hongjin Liang, Xiaolan Chang
Publikováno v:
FEBS Letters. 593:1061-1071
Homocysteine (Hcy) is associated with nonalcoholic fatty liver disease (NAFLD). orphan nuclear receptor subfamily 4 group A member 1 (NR4A1) is involved in hepatic lipid metabolism. However, the potential role of NR4A1 in Hcy-associated NAFLD remains
Publikováno v:
FEBS Letters. 592:394-401
Little is known about the iron efflux mechanism in adipocytes. Here, we used hephaestin (Heph) and ceruloplasmin (Cp) single-knockout (KO) mice and Heph/Cp double-KO mice to investigate the roles of multicopper ferroxidases (MCFs) in this process. We
Autor:
Hideyuki Suzuki, Takafumi Mizushige, Hayato Aoki, Ryuhei Kanamoto, Kousaku Ohinata, Hiroshi Iwakura, Masaru Sato, Junya Nakato
Publikováno v:
FEBS Letters. 591:2121-2130
Ghrelin, an endogenous peptide isolated from the stomach, is known to stimulate food intake after peripheral administration. We found that the enzymatic digest of β-lactoglobulin decreases ghrelin secretion from the ghrelin-producing cell line MGN3-
Autor:
Meng-Long Zhao, Mei-Nan Yao, Xiao-Huan Liang, Hai-Tin Dou, Wenbo Deng, Yue-Fang Liu, Shu-Yun Li, Zeng-Ming Yang, Jie Liu
Publikováno v:
FEBS Letters. 590:2594-2602
Lipocalin-2 (Lcn2) is a small glycoprotein involved in a number of biological processes such as inflammation and antibacterial response. In our study, Lcn2 is expressed in the subluminal stromal cells at implantation site on day 5 of pregnancy. The e