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Autor:
Mingming Xu, Jinyu Li, Peng Xu, Mingdong Huang, Peter A. Andreasen, Longguang Jiang, Yayu Chen
Publikováno v:
Xu, M, Chen, Y, Xu, P, Andreasen, P A, Jiang, L, Li, J & Huang, M 2018, ' Crystal structure of plasma kallikrein reveals the unusual flexibility of the S1 pocket triggered by Glu217 ', FEBS Letters, vol. 592, no. 15, pp. 2658-2667 . https://doi.org/10.1002/1873-3468.13191
Serine proteases play important roles in numerous physiological and pathophysiological processes. Moreover, serine proteases are classical subjects for studies of catalytic and inhibitory mechanisms of enzymes. Here, we determined the crystal structu
Autor:
Chuan Li, Tetsuya Fukui, Shinya Hasegawa, Daiki Inoue, Masahiko Imai, Noriko Takahashi, Masahiro Yamasaki
Publikováno v:
FEBS Letters. 590:1592-1601
Acetoacetyl-CoA synthetase (AACS) is a ketone body-utilizing enzyme and is responsible for the synthesis of cholesterol and fatty acids. We have previously shown that AACS is cleaved by legumain, a lysosomal asparaginyl endopeptidase. In this study,
Publikováno v:
FEBS Letters. 588:3427-3434
The present study explored the involvement of miR-302a in adipocyte differentiation via interaction with 3′-untranslated region of peroxisome proliferator-activated receptor gamma (PPARγ) mRNA. In differentiating 3T3-L1 adipocytes, expression of m
Autor:
Alfred H. Merrill, Robert C. Dickson, Lindsay M. Andras, Jia Wei, Hee Sook Kim, M. Marek Nagiec, Stephen C. Linn
Publikováno v:
FEBS Letters. 580:6217-6223
A series of luciferase reporter constructs was prepared from a 1035-bp fragment of mouse genomic DNA flanking the 5′-coding sequence for the SPTLC2 subunit of serine palmitoyltransferase, the initial enzyme of de novo sphingolipid biosynthesis. The
Publikováno v:
FEBS Letters. 551:63-70
Glucosamine-6-phosphate deaminase (EC 3.5.99.6) is an allosteric enzyme that catalyzes the reversible conversion of D -glucosamine-6-phosphate into D -fructose-6-phosphate and ammonium. Here we describe the existence of two mammalian glucosamine-6-ph
Autor:
I Bushkin-Harav, Uriel Z. Littauer
Publikováno v:
FEBS Letters. 424:243-247
We have examined the mechanism of signaling by the 67 kDa YIGSR binding protein of laminin and its properties in neuroblastoma cells. Ligand displacement analysis showed that the interaction with the C(YIGSR)3-NH2 peptide amide is of intermediate aff
Autor:
Berhane Ghebrehiwet, Nicholas J. Lynch, Wallace B.L Lim, Mohamed R. Daha, Leonora A.E. Leigh, Wilhelm J. Schwaeble, Rocco H. van den Berg, Kenneth B.M. Reid
Publikováno v:
FEBS Letters. 418:111-114
gC1qBP is a 33 kDa glycoprotein that binds to the globular `heads' of C1q. We have cloned cDNAs encoding the rat and mouse homologues of gC1qBP. Comparison of the cDNA-derived amino acid sequences of gC1qBP reveals that either of the rodent sequences
Autor:
Indra Poola
Publikováno v:
FEBS Letters. 416:139-142
We have previously described an estrogen inducible, intracellular, homodimeric membrane glycoprotein (subunit Mr 104 kDa) which is structurally related to `chaperone' proteins (Poola, I. and Kiang J.G., J. Biol. Chem. 269 (1994) 21762–21769). In th
Autor:
Takeshi Imanishi, Tatsuhiko Kodama, Toshiki Tanaka, Koji Yamamoto, Kazuo Suzuki, Noriyasu Nishimura, Takefumi Doi
Publikováno v:
FEBS Letters. 414:182-186
Scavenger receptors bind modified low-density lipoproteins (LDL) on a collagen-like domain which possesses a lysine cluster at the car☐y end. We previously constructed a receptor model peptide containing the lysine cluster. In the present study, we
Publikováno v:
FEBS Letters. 393:269-272
We have cloned and overexpressed rat 4-hydroxyphenylpyruvate dioxygenase (4HPPD) in Escherichia coli. The soluble, active recombinant enzyme was shown to contain both 4HPPD and α-ketoisocaproate dioxygenase (αKICD) activity. However, upon truncatio