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Autor:
Mingming Xu, Jinyu Li, Peng Xu, Mingdong Huang, Peter A. Andreasen, Longguang Jiang, Yayu Chen
Publikováno v:
Xu, M, Chen, Y, Xu, P, Andreasen, P A, Jiang, L, Li, J & Huang, M 2018, ' Crystal structure of plasma kallikrein reveals the unusual flexibility of the S1 pocket triggered by Glu217 ', FEBS Letters, vol. 592, no. 15, pp. 2658-2667 . https://doi.org/10.1002/1873-3468.13191
Serine proteases play important roles in numerous physiological and pathophysiological processes. Moreover, serine proteases are classical subjects for studies of catalytic and inhibitory mechanisms of enzymes. Here, we determined the crystal structu
Autor:
Chuan Li, Tetsuya Fukui, Shinya Hasegawa, Daiki Inoue, Masahiko Imai, Noriko Takahashi, Masahiro Yamasaki
Publikováno v:
FEBS Letters. 590:1592-1601
Acetoacetyl-CoA synthetase (AACS) is a ketone body-utilizing enzyme and is responsible for the synthesis of cholesterol and fatty acids. We have previously shown that AACS is cleaved by legumain, a lysosomal asparaginyl endopeptidase. In this study,
Publikováno v:
FEBS Letters. 551:63-70
Glucosamine-6-phosphate deaminase (EC 3.5.99.6) is an allosteric enzyme that catalyzes the reversible conversion of D -glucosamine-6-phosphate into D -fructose-6-phosphate and ammonium. Here we describe the existence of two mammalian glucosamine-6-ph
Autor:
I Bushkin-Harav, Uriel Z. Littauer
Publikováno v:
FEBS Letters. 424:243-247
We have examined the mechanism of signaling by the 67 kDa YIGSR binding protein of laminin and its properties in neuroblastoma cells. Ligand displacement analysis showed that the interaction with the C(YIGSR)3-NH2 peptide amide is of intermediate aff
Autor:
Indra Poola
Publikováno v:
FEBS Letters. 416:139-142
We have previously described an estrogen inducible, intracellular, homodimeric membrane glycoprotein (subunit Mr 104 kDa) which is structurally related to `chaperone' proteins (Poola, I. and Kiang J.G., J. Biol. Chem. 269 (1994) 21762–21769). In th
Publikováno v:
FEBS Letters. 393:269-272
We have cloned and overexpressed rat 4-hydroxyphenylpyruvate dioxygenase (4HPPD) in Escherichia coli. The soluble, active recombinant enzyme was shown to contain both 4HPPD and α-ketoisocaproate dioxygenase (αKICD) activity. However, upon truncatio
Publikováno v:
FEBS letters. 371(2)
Clostridium botulinum C3 exoenzyme specifically ADP-ribosylates rho-p21 in eukaryotic cells. Trp18 and Glu173 of this enzyme were substituted with other amino acids via site-directed mutagenesis. All substitutions at Glu173 caused a significant reduc
Autor:
Jacques Aubry, Alain Zachowski
Publikováno v:
FEBS Letters. 70:201-204
A number of studies have suggested that some biological membrane functions might be correlated with the physical state of the phospholipids in these membranes [l-4] . Breaks in the Arrhenius plots of enzymatic or transport activities have indicated a
Autor:
Matti Saraste
Publikováno v:
FEBS Letters. 166:367-372
Amino acid sequences of 6 mitochondrial cytochromes b are analysed to locate the binding sites of the two protohaems. Four invariant histidines are found in two protein segments which span the membrane. In each, two histidines are separated by 13 res
Publikováno v:
FEBS Letters. (3):465-468
The Ca2+-free form of calmodulin (CaM), apocalmodulin (ApoCaM), regulates a variety of target proteins including nitric oxide synthase II (NOS-II). The CaM-binding site of NOS-II can bind ApoCaM with high affinity. Substitution of hydrophobic amino a