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Publikováno v:
FEBS Letters. 594:841-850
The hirudin-like factor 1 (HLF1) of Hirudo medicinalis belongs to a new class of leech-derived factors. In previous investigations, HLF1 did not exhibit anticoagulatory activities. Here, we describe the analysis of natural and synthetic variants of H
Publikováno v:
FEBS Letters. 591:1010-1017
It has been proposed that invertebrate stimulators of interferon genes (STINGs) do not take part in the innate immune response to infection. Herein, we identified a new STING homolog from pacific white shrimp Litopenaeus vannamei (LvSTING). Some amin
Publikováno v:
FEBS Letters. 588:28-34
Paramyxovirus C protein targets the host interferon (IFN) system for virus immune evasion. To identify its unknown anti-IFN activity, we examined the effect of Sendai virus C protein on activation of the IFN-α promoter via various signaling pathways
Publikováno v:
FEBS Letters. 584:4627-4632
Several RNA viruses can be detected by the inflammasome, which promotes IL-1β and IL-18 secretion, but the underlying mechanisms of detection remain unclear. Cytosolic dsRNA is a replication intermediate of many RNA viruses. We show here that transf
Autor:
Jacek Jemielity, Andrzej Guranowski, Jarosław Zimny, Anna Maria Wojdyła, Paweł Bieganowski, Richard E. Davis, Anna Wypijewska, Joanna Kowalska
Publikováno v:
FEBS Letters. 584:93-98
Histidine triad (HIT)-family proteins interact with different mono- and dinucleotides and catalyze their hydrolysis. During a study of the substrate specificity of seven HIT-family proteins, we have shown that each can act as a sulfohydrolase, cataly
Publikováno v:
FEBS Letters. 583:401-406
Proteasome inhibition has emerged as a powerful option for the treatment of a number of malignancies including leukemias. However, Bortezomib showed limited single-agent activity for patients with leukemia. Here, we report for the first time that Bor
Publikováno v:
FEBS Letters. 582:1087-1092
Resonance Raman spectroscopy was applied to monitor the effects of chloroquine (CQ) treatment on cultures of Plasmodium falciparum trophozoites. A number of bands assigned to A1g and B1g modes characteristic of the haemozoin aggregate are reduced in
Publikováno v:
FEBS Letters. 581:483-488
The purinergic receptor P2X(7) is part of a complex signaling mechanism participating in a variety of physiological and pathological processes. Depending on the activation scheme, P2X(7) receptors in vivo are non-selective cation channels or form lar
Publikováno v:
FEBS Letters. 579:6395-6402
The protozoan parasite Entamoeba histolytica expresses a cytosine-5 DNA methyltransferase (Ehmeth) that belongs to the DNMT2 protein family. The biological function of members of this DNMT2 family is unknown. In the present study, the 5′ region of
Autor:
Horia Vais, Peter N.R. Usherwood, Thomas G. Davies, Martin S. Williamson, Bhupinder P. S. Khambay
Publikováno v:
FEBS Letters. 579:6317-6325
DDT inhibits Na channel inactivation and deactivation, promotes Na channel activation and reduces the resting potential of Xenopus oocytes expressing the Drosophila para Na channel. These changes are only marginally influenced by the single mutation