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Autor:
Mingming Xu, Jinyu Li, Peng Xu, Mingdong Huang, Peter A. Andreasen, Longguang Jiang, Yayu Chen
Publikováno v:
Xu, M, Chen, Y, Xu, P, Andreasen, P A, Jiang, L, Li, J & Huang, M 2018, ' Crystal structure of plasma kallikrein reveals the unusual flexibility of the S1 pocket triggered by Glu217 ', FEBS Letters, vol. 592, no. 15, pp. 2658-2667 . https://doi.org/10.1002/1873-3468.13191
Serine proteases play important roles in numerous physiological and pathophysiological processes. Moreover, serine proteases are classical subjects for studies of catalytic and inhibitory mechanisms of enzymes. Here, we determined the crystal structu
Autor:
Hideyuki Suzuki, Takafumi Mizushige, Hayato Aoki, Ryuhei Kanamoto, Kousaku Ohinata, Hiroshi Iwakura, Masaru Sato, Junya Nakato
Publikováno v:
FEBS Letters. 591:2121-2130
Ghrelin, an endogenous peptide isolated from the stomach, is known to stimulate food intake after peripheral administration. We found that the enzymatic digest of β-lactoglobulin decreases ghrelin secretion from the ghrelin-producing cell line MGN3-
Publikováno v:
FEBS Letters. 551:63-70
Glucosamine-6-phosphate deaminase (EC 3.5.99.6) is an allosteric enzyme that catalyzes the reversible conversion of D -glucosamine-6-phosphate into D -fructose-6-phosphate and ammonium. Here we describe the existence of two mammalian glucosamine-6-ph
Autor:
Masaaki Yoshikawa, Takahiro Tsuruki, Katsuki Kishi, Masakazu Takahashi, Taiji Matsukawa, Makoto Tanaka
Publikováno v:
FEBS Letters. 540:206-210
A tridecapeptide (MITLAIPVNKPGR) that stimulates phagocytosis of human neutrophils was isolated from a trypsin digest of soybean proteins. This peptide is derived from the soybean beta-conglycinin alpha' subunit and was named soymetide-13. The N-term
Publikováno v:
FEBS Letters. 533:115-118
Protein engineering allows the generation of hybrid polypeptides with functional domains from different origins and therefore exhibiting new biological properties. We have explored several permissive sites in Escherichia coli β-galactosidase to gene
Autor:
Carmen Diaz, Hans Peter Rahn, Oriol Bachs, Neus Agell, Aina Rodríguez-Vilarrupla, Núria Canela
Publikováno v:
FEBS Letters. 531:319-323
Overexpression of p21(cip1) induces cell cycle arrest. Although this ability has been correlated with its nuclear localization, the evidence is not conclusive. The mutants that were used to inhibit its nuclear translocation could no longer bind to se
Autor:
Geoffrey Goldspink, Shi Yu Yang
Publikováno v:
FEBS Letters. 522:156-160
The physiological function of a recently cloned splice variant of insulin-like growth factor-I (IGF-I; mechano growth factor (MGF)) was studied using an in vitro cell model. Unlike mature IGF-I, the distinct E domain of MGF inhibits terminal differen
Autor:
Michinori Tanaka, Masako Takikawa, Takao Taki, Dai Ishikawa, Koichi Ogino, Naoto Yamaguchi, Tomohiro Asai, Naoto Oku, Hironori Kikkawa
Publikováno v:
FEBS Letters. 466:381-384
GD1alpha ganglioside-replica peptides were recently isolated from a phage-displayed random pentadecapeptide library by assaying for inhibition of adhesion of RAW117-H10 lymphosarcoma cells to hepatic sinusoidal microvessel endothelial (HSE) cells. We
Publikováno v:
FEBS Letters. 441:20-24
A novel peptide technology to produce mimicking peptides of carbohydrate moiety (which we propose to name glyco-replica peptides) is a useful tool to elucidate the functions of glycoconjugate. Carbohydrate moiety of ganglioside GD1alpha functions as
Publikováno v:
FEBS Letters. 418:101-105
The cytotoxic properties of an amphiphilic synthetic peptide are presented. Comparative analysis of proliferating, differentiated and confluent H9C2 adherent cells and L1210 cells in suspension shows a correlation between toxicity and cell stage (pro