Zobrazeno 1 - 10
of 19
pro vyhledávání: ''
Publikováno v:
FEBS Letters. 595:1313-1321
The molecular mechanisms generating the mania-like abnormal behaviors caused by diacylglycerol (DG) kinase (DGK) η deficiency remain unclear. Here, we found that DGKη knockout markedly increased dopamine (DA) levels in the midbrain (DA-producing re
Autor:
Alexander Bartelt, Gökhan S. Hotamisligil, Martin D. Brand, Michael Schlame, Renata L.S. Goncalves
Publikováno v:
Febs Letters
Barth syndrome (BTHS) is a rare X-linked genetic disorder caused by mutations in the gene encoding the transacylase tafazzin and characterized by loss of cardiolipin and severe cardiomyopathy. Mitochondrial oxidants have been implicated in the cardio
Autor:
Ting Su, Dongyang Huang, Xina Xie, Bin Liang, Meihui Huang, Xuhong Song, Hongjin Liang, Xiaolan Chang
Publikováno v:
FEBS Letters. 593:1061-1071
Homocysteine (Hcy) is associated with nonalcoholic fatty liver disease (NAFLD). orphan nuclear receptor subfamily 4 group A member 1 (NR4A1) is involved in hepatic lipid metabolism. However, the potential role of NR4A1 in Hcy-associated NAFLD remains
Autor:
Denis, Raphaël, Busi, Florent, Castel, Julien, Morel, Chloé, Zhang, Wenchao, Bui, Linh-Chi, Sugamori, Kim, Prokopec, Stephenie, Boutros, Paul, Grant, Denis, Rodrigues-Lima, Fernando, Luquet, Serge, Dupret, Jean-Marie, Denis, Raphaël G.P., Bui, Linh‐Chi, Rodrigues‐Lima, Fernando, Dupret, Jean‐Marie
Publikováno v:
FEBS Letters
FEBS Letters, Wiley, 2019, 593 (8), pp.831-841. ⟨10.1002/1873-3468.13357⟩
FEBS Letters, Wiley, 2019, 593 (8), pp.831-841. ⟨10.1002/1873-3468.13357⟩
International audience; Recent studies have revealed a possible link between the activities of polymorphic arylamine N-acetyltransferases (NATs) and energy metabolism. We used a Nat1/Nat2 double knockout (KO) mouse model to demonstrate that ablation
Autor:
Masayuki Shimano, Rei Shibata, Toyoaki Murohara, Noriyuki Ouchi, Kazuhisa Kondo, Gennaro Galasso, Shinji Kihara, Carsten Skurk, Kenneth Walsh, Taiki Ohashi
Publikováno v:
FEBS Letters. 582:1607-1612
Obesity-linked diseases are associated with suppressed endothelial progenitor cell (EPC) function. Adiponectin is an adipose-derived protein that is downregulated in obese and diabetic subjects. Here, we investigated the effects of adiponectin on EPC
Publikováno v:
FEBS Letters. 580:3853-3859
The Eyes Absent (Eya) proteins are tyrosine phosphatases and transcriptional activators involved in cell-fate determination and organ development. Mutations in the gene encoding Eya homologue 1 have been implicated in the multi-organ developmental di
Publikováno v:
FEBS Letters. 580:711-715
Using MIN6 beta-cells and chromatin immunoprecipitation (ChIP) assays, the chronological sequence of binding of MafA, E47/beta2 and PDX-1 to the insulin promoter in living beta-cells were investigated. All four factors were shown to bind to the mouse
Autor:
Geoffrey Goldspink, Shi Yu Yang
Publikováno v:
FEBS Letters. 522:156-160
The physiological function of a recently cloned splice variant of insulin-like growth factor-I (IGF-I; mechano growth factor (MGF)) was studied using an in vitro cell model. Unlike mature IGF-I, the distinct E domain of MGF inhibits terminal differen
Autor:
Anne-Catherine Andres, Franziska Kuhn
Publikováno v:
FEBS Letters. 413:65-69
The acquisition of invasive properties is a crucial event during carcinogenesis, determining the clinical outcome. The mammary gland at puberty provides an ideal model for investigating the induction and control of invasive growth. During this growth
Autor:
David J. Lamb, David S. Leake
Publikováno v:
FEBS Letters. 338:122-126
LDL oxidation within the arterial wall may contribute to the disease of atherosclerosis. There is some evidence that elevated plasma levels of copper are associated with an increased risk of coronary artery disease. We have investigated the condition