Zobrazeno 1 - 10
of 23
pro vyhledávání: ''
Autor:
Liling Zhang, Allen Volchuk
Publikováno v:
FEBS Letters. 584:2298-2304
The p24 protein family have multiple functions in protein transport in the early secretory pathway. In this study we examined the role of p24 proteins in insulin transport. Several members were detected in insulinoma cell lines and rat islets and exp
Publikováno v:
FEBS Letters. 580:3617-3623
Protein-mediated LCFA transport across plasma membranes is highly regulated by the fatty acid transporters FAT/CD36 and FABPpm. Physiologic stimuli (insulin stimulation, AMP kinase activation) induce the translocation of one or both transporters to t
Autor:
Louis Hue, Christophe Beauloye, Jean-Louis Vanoverschelde, D. Grahame Hardie, Luc Bertrand, Ulrike Krause, Anne-Sophie Marsin
Publikováno v:
FEBS Letters. 505:348-352
AMP-activated protein kinase (AMPK) is known to be activated by phosphorylation on Thr172 in response to an increased AMP/ATP ratio. We report here that such an activation indeed occurred in anaerobic rat hearts and that it was antagonized (40–50%)
Autor:
Donal O'Shea, Mandy D. Turton, S. Rasheed, Melanie M. Heath, Jane K. Howard, M. Rossi, C. Mark B. Edwards, Joanna Steere, Karim Meeran, M. A. Ghatei, Kim M. Moar, Caroline J. Small, Nigel Hoggard, Julian G. Mercer, I. Gunn, Anthony P. Goldstone, Stephen R. Bloom
Publikováno v:
FEBS Letters. 415:134-138
The adipose tissue hormone, leptin, and the neuropeptide glucagon-like peptide-1 (7–36) amide (GLP-1) both reduce food intake and body weight in rodents. Using dual in situ hybridization, long isoform leptin receptor (OB-Rb) was localized to GLP-1
Publikováno v:
FEBS Letters. 410:515-519
Glucagon-37 is secreted by intestinal L-cells following carbohydrate uptake. It is known to inhibit gastric acid secretion (hence also named oxyntomodulin) and appears to increase intracellular cyclic AMP concentrations. Since cyclic AMP could enhanc
Publikováno v:
FEBS Letters. 379:7-10
Studies using an inhibitor of nitric oxide (NO) synthesis have suggested that endogenous NO may have a role in regulating endothelin release. We investigated the effect of endogenous and exogenous nitric oxide (NO) on the release of irET-1. l -NAME s
Publikováno v:
FEBS Letters. 361:51-54
In skeletal muscle, glucose transport is stimulated by insulin, contractions and hypoxia. In this study, we used the phosphatidylinositol 3-kinase (PI 3-kinase) inhibitor wortmannin to examine whether (i) PI 3-kinase activity is necessary for stimula
Publikováno v:
FEBS Letters 581 (2007) 29
FEBS Letters, 581(29), 5617-5626
FEBS Letters, 581(29), 5617-5626
A tight hormonal control of energy homeostasis is of pivotal relevance for animals. Recent evidence suggests an involvement of the nuclear receptor NR1i3 (CAR). Fasting induces CAR by largely unknown mechanisms and CAR-deficient mice are defective in
Autor:
Nicolas Simon, Saïk Urien, Roland Zini, Christophe Morin, Jean-Paul Tillement, Pascale Jolliet
Publikováno v:
FEBS Letters
FEBS Letters, Wiley, 1998, 435 (1), pp.25-28. ⟨10.1016/S0014-5793(98)01033-3⟩
FEBS Letters, Wiley, 1998, 435 (1), pp.25-28. ⟨10.1016/S0014-5793(98)01033-3⟩
The importance of mitochondria is rising as a target in pathologic processes such as ischemia. We have investigated the effects of hydrocortisone, prednisolone, dexamethasone and triamcinolone on oxidative phosphorylation, Ca2+ fluxes, swelling and m
Autor:
Kurt Jungermann, Frank Stümpel
Publikováno v:
FEBS letters. 406(1-2)
In vivo, insulin increases net hepatic glucose uptake efficiently only in the presence of a portal-arterial glucose gradient. In isolated perfused rat livers supplied with a glucose gradient (portal 10 mM/arterial 5 mM) insulin-induced glucose uptake