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Autor:
Marc L. Reitman
Publikováno v:
FEBS Letters. 592:2098-2107
Mice are widely used for exploring obesity physiology and treatment. However, thermal biology is different between small and large mammals. In this Review, we discuss how the effect of environmental temperature must be understood to ensure applicabil
Autor:
Silvestre J. Sanchez, Derick Han, Jerome Garcia, Carl W. Decker, Jeffrey M. Ouk, Krysta M. Siu
Publikováno v:
FEBS Letters. 592:916-927
We investigated if obesity/steatosis promotes mitochondrial remodeling in the liver of ob/ob mice (an obesity model). Liver mitochondria from ob/ob mice (21 weeks with significant steatosis) had ~ 2-fold increases in state III respiration compared wi
Publikováno v:
FEBS Letters. 592:394-401
Little is known about the iron efflux mechanism in adipocytes. Here, we used hephaestin (Heph) and ceruloplasmin (Cp) single-knockout (KO) mice and Heph/Cp double-KO mice to investigate the roles of multicopper ferroxidases (MCFs) in this process. We
Autor:
Nadja Mingirulli, Verónica I. Dumit, Janbernd Kirschner, Zeinab Wehbe, Sara Tucci, Ute Spiekerkoetter
Publikováno v:
FEBS Letters. 592:219-232
The white skeletal muscle of very long-chain acyl-CoA-dehydrogenase-deficient (VLCAD-/- ) mice undergoes metabolic modification to compensate for defective β-oxidation in a progressive and time-dependent manner by upregulating glucose oxidation. Thi
Autor:
Xiao-Huan Liang, Yue-Fang Liu, Min-Jie Song, Zeng-Ming Yang, Jia-Wen Qin, Jia-Qi Yan, Shu-Yun Li, Zhuo Song
Publikováno v:
FEBS Letters. 591:1394-1407
The establishment of decidualization is a prerequisite of successful pregnancy. Lysyl oxidase (Lox) is a copper-containing amine oxidase which catalyzes cross-linking of collagen and elastin in the ECM. Lox is expressed in the subluminal stroma surro
Autor:
Shoen Kume, Kahoko Umeda, Naomi Nakagata, Naoki Takeda, Hisayoshi Omori, Soichiro Ogaki, Mutsumi Sato, Daisuke Sakano
Publikováno v:
Febs Letters
C2cd4c, encoded by a gene belonging to the C2cd4 family, contains a C2 domain conserved across species and is localized to the cytoplasm. To examine the role of C2cd4c in the pancreas, we studied its localization and generated C2cd4c knockout (KO) mi
Publikováno v:
FEBS Letters. 590:1614-1629
Here, we investigate the mechanism through which paraoxonase 1 (PON1) may regulate cholesterol efflux. Pretreatment of oxLDL with PON1 (oxLDL-PON1) contributed to the formation of LysoPC. In J774 macrophages, oxLDL-PON1 increased cholesterol efflux b
Autor:
Pingjin Gao, Ling-Ran Kong, Li-Juan Sheng, Cheng-Chao Ruan, Yu Ma, Dingliang Zhu, Dong-Rui Chen
Publikováno v:
FEBS Letters. 590:769-778
Beta3 adrenergic receptor (ADRB3) mediates vessel relaxation in the endothelium while it modulates lipolysis in the adipose tissue. However, the function and regulation mechanism of ADRB3 in the perivascular adipose tissue (PVAT), especially in hyper
Autor:
Linqiang Li, Jiancheng Yang, Leigh Darryl Quarles, Gwendalyn D. King, Xiaobin Han, Zhousheng Xiao
Publikováno v:
FEBS Letters. 590:53-67
Mechanisms underlying the association between fibroblastic growth factor 23 (FGF-23) and inflammation are uncertain. We found that FGF-23 was markedly up-regulated in LPS/INF-γ-induced proinflammatory M1 macrophages and Hyp mouse-derived peritoneal
Publikováno v:
FEBS letters. 591(1)
Rat perivascular adipose tissue (PVAT) stores, takes up, and releases norepinephrine (NE; Ayala-Lopez et al. (2014) Pharmacol Res Perspect 2, e00041). We hypothesized that 3T3-L1 adipocytes would exhibit similar behaviors and, thus, could serve as a