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Thyrotropin and norepinephrine stimulate the metabolism of phosphoinositides in FRTL-5 thyroid cells
Autor:
Evelyn F. Grollman, Nancy Philp
Publikováno v:
FEBS Letters. (2):193-196
Hormone-induced changes in phospholipid metabolism were examined in a functioning rat thyroid cell line (FRTL-5). Stimulation of FRTL-5 cells, prelabeled with 32P, with TSH or NE resulted in a rapid decrease in the radioactivity of both phosphatidyli
Autor:
Ruth S. Gurd, Naseema M. Hoosein
Publikováno v:
FEBS Letters. (1):83-86
Two human glucagon-like peptides, GLP-1 and GLP-2, which are coencoded with pancreatic glucagon in the preproglucagon gene, do not significantly inhibit [125I]monoiodoglucagon binding to rat liver and brain membranes and do not activate adenylate cyc
Publikováno v:
FEBS Letters. (1):107-112
The diterpene forskolin maximally stimulated bovine adrenal cortex adenylate cyclase activity 9-fold with a concentration producing half-maximum effect (ED 50 ) of about 4 μM. The effects of forskolin and the fully active corticotropin fragment ACTH
Publikováno v:
FEBS Letters. (2):196-200
The phorbol ester TPA (12-O-tetradecanoyl phorbol-13-acetate) causes a dose-dependent inhibition of the glucagon-stimulated adenylate cyclase activity expressed in plasma membranes isolated from TPA-treated hypatocytes. However, no observable inhibit
Publikováno v:
FEBS Letters. (1):83-88
The discovery of prostacyclin [l] opened a new area of prostaglandin research. PGIz is a potent stimulator of the adenylate cyclase-cyclic AMP (CAMP) system [2,3] and is considered to be an important regulator of cell metabolism. We have shown that c
Publikováno v:
FEBS Letters. (2):163-168
Isoproterenol or forskolin induce a 10-15-fold increase in concentration of cyclic AMP in rat reticulocytes as compared with the basal level of 2.3 +/- 0.3 microM. Glycolysis is stimulated by both compounds transiently more than 2-fold with a peak af
Publikováno v:
FEBS Letters. (1):88-92
The influence of islet-activating protein (IAP), a Bordetella pertussis toxin, was studied on adenylate cyclase and GTPase activities in rat adipocyte membranes. Pretreatment of rats or intact rat adipocytes with IAP did not affect adenylate cyclase
Autor:
Michihisa Tohda, Yasuyuki Nomura
Publikováno v:
FEBS Letters. (1):40-44
Depolarized stimulation 1.5-fold increased Ca2+ influx which was inhibited by pretreatment with verapamil or LaCl3. Treatment with pertussis toxin, islet-activating protein (IAP), induced a reduction in 50 mM K+- induced Ca2+ influx and stimulated ad
Publikováno v:
FEBS Letters. (2):159-162
Publikováno v:
FEBS Letters. (1):113-116
UV irradiation of Xenopus laevis melanophores in the presence of photoreactive [Pap13]-ol-MSH induces irreversible pigment dispersion [ 13. It appears that specific covalent labelling of MSH receptors results in the generation of a continuous signall