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Publikováno v:
FEBS Letters. (1):13-16
The number of dihydropyridine receptors (DHPR) and sarcoplasmic reticulum (SR) Ca2+ release channels (RyR1) and their interaction determine the efficacy of the sarcolemmal excitation-SR Ca2+ release-contraction coupling (ECC). Both receptors play a c
Autor:
Kirsten Leineweber, Simon Kochhäuser, Gerd Hasenfuss, Karl Toischer, Harald Kögler, Phuc Nguyen Van
Publikováno v:
FEBS Letters. (9):1363-1369
Proteins are folded in the endoplasmic reticulum (ER). ER stress initially leads to compensatory upregulation of ER chaperones and later to apoptosis, but the contribution of biomechanical load vs. neurohumoral stress to myocardial ER stress is unkno
Publikováno v:
FEBS Letters. (2):229-232
TRPA1 channels are non-selective cation channels activated by plant derived pungent products including allyl isothiocyanate (AITC) from mustard. Therefore, possible intestinal secretory functions of these channels were investigated. We detected TRPA1
Publikováno v:
FEBS Letters. (9):1345-1349
The recent creation of the PANDER (pancreatic-derived factor) knockout (PANKO) and acute mouse models have revealed a biological function in the regulation of glycemic levels via promotion of hepatic glucose production (HGP) and pancreatic β-cell in
Autor:
Jean-Paul Giacobino, Kriss Canola, Patrick Muzzin, Françoise Kuehne, Cedric S. Asensio, Lorenz Lehr, Maria Jimenez
Publikováno v:
FEBS Letters. (19):4661-4666
In rodent brown adipose tissue, the beta-adrenergic signaling is believed, by an action on PGC-1alpha, to control UCP1 expression and mitochondriogenesis. We addressed this hypothesis using beta(1)/beta(2)/beta(3)-adrenoceptor knockout (beta-less) br
Publikováno v:
FEBS Letters. (11):1687-1692
The purpose of this study was to examine the effects of sarcolipin (SLN) on sarco(endo) plasmic reticulum Ca(2+)-ATPase (SERCA pump) energetics in vivo and resting skeletal muscle metabolic rate. Using SLN knockout (Sln(-/-)) mice we show that SLN ab
Autor:
Majambu Mbikay, Andrew Chen, Thilina Dewpura, Francine Sirois, Michel Chrétien, Fraser W. Scott, Annik Prat, Gen-Sheng Wang, Janice Mayne, Nabil G. Seidah
Publikováno v:
FEBS Letters. (4):701-706
Proprotein convertase subtilisin/kexin type 9 (PCSK9), a liver-secreted plasma enzyme, restricts hepatic uptake of low-density lipoprotein (LDL) cholesterol by promoting the degradation of LDL receptors (LDLR). PCSK9 and LDLR are also expressed in in
Publikováno v:
FEBS Letters. (19):4259-4267
Estrogen depletion following menopause has been correlated with an increased risk of developing Alzheimer’s disease (AD). We previously explored the beneficial effect of (−)-epigallocatechin-3-gallate (EGCG) on AD mice and found increased non-amy
Autor:
Olga Matejkova, Jana Sponarova, Martin Rossmeisl, Jan Kopecky, Pavel Flachs, Ivan Mikšík, Kirsty J. Mustard, Michaela Thomason-Hughes, D. Grahame Hardie
Publikováno v:
FEBS Letters. (1-3):245-248
The AMP-activated protein kinase (AMPK) cascade is a sensor of cellular energy charge that promotes catabolic and inhibits anabolic pathways. However, the role of AMPK in adipocytes is poorly understood. We show that transgenic expression of mitochon