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Publikováno v:
FEBS Letters. 595:2493-2503
Nonalcoholic fatty liver disease (NAFLD) can lead to hepatocellular carcinoma (HCC). The level of the transcription factor SOX2 correlates with HCC progression, but its role in fat accumulation remains unclear. Here, a high-fat diet, with and without
Autor:
Norihiro Tada, Yoko Fujiwara, Hyeon-Cheol Lee-Okada, Eri Nakamura, Ikuyo Ichi, Takehiko Yokomizo, Yuri Hayashi
Publikováno v:
FEBS Letters. 595:1920-1932
Deficiency of polyunsaturated fatty acids (PUFAs) is known to induce hepatic steatosis. However, it is not clearly understood which type of PUFA is responsible for the worsening of steatosis. This study observed a marked accumulation of hepatic triac
Autor:
Shouhai Zhu, Shufeng Xie, Han Liu, Dan Li, Zhihong Chen, Ruiheng Wang, Qiongyu Xu, Xiaoyan Cheng, Maolin Ge
Publikováno v:
FEBS Letters. 595:462-475
Transplantation of in vitro-manipulated cells is widely used in hematology. While transplantation is well recognized to impose severe stress on transplanted cells, the nature of transplant-induced stress remains elusive. Here, we propose that the lac
Autor:
Marios P. Stavridis, Mehmet Gundogdu, Sergio G. Bartual, Daan M. F. van Aalten, Andrew T. Ferenbach, Riina Žordania, Katrin Õunap, Veronica M. Pravata, Monica H. Wojcik, Sander Pajusalu
Publikováno v:
Febs Letters
'FEBS Letters ', vol: 594, pages: 717-727 (2020)
'FEBS Letters ', vol: 594, pages: 717-727 (2020)
X‐linked intellectual disabilities (XLID) are common developmental disorders. The enzyme O‐GlcNAc transferase encoded by OGT, a recently discovered XLID gene, attaches O‐GlcNAc to nuclear and cytoplasmic proteins. As few missense mutations have
Autor:
Naoyuki Taniguchi, Yasuhiko Kizuka, Hiromasa Inoue, Yoichiro Harada, Hirokazu Yagi, Ikuro Maruyama, Yuko Tokoro, Koichi Kato, Kiyotaka Kondo
Publikováno v:
Febs Letters
We investigated the correlation between metastatic behaviors of tumor cells and asparagine-linked glycosylation (N-glycosylation) of tumor-derived extracellular vesicles (EVs). Three mouse melanoma B16 variants with distinct metastatic potentials sho
Autor:
Mingming Xu, Jinyu Li, Peng Xu, Mingdong Huang, Peter A. Andreasen, Longguang Jiang, Yayu Chen
Publikováno v:
Xu, M, Chen, Y, Xu, P, Andreasen, P A, Jiang, L, Li, J & Huang, M 2018, ' Crystal structure of plasma kallikrein reveals the unusual flexibility of the S1 pocket triggered by Glu217 ', FEBS Letters, vol. 592, no. 15, pp. 2658-2667 . https://doi.org/10.1002/1873-3468.13191
Serine proteases play important roles in numerous physiological and pathophysiological processes. Moreover, serine proteases are classical subjects for studies of catalytic and inhibitory mechanisms of enzymes. Here, we determined the crystal structu
Autor:
René Rezsohazy, Magali Belpaire, Hervé Degand, Pierre Morsomme, Laure Bridoux, Tamara Pringels, Amandine Draime
Publikováno v:
FEBS Letters. 592:1185-1201
HOXA1 belongs to the HOX family of transcription factors which are key regulators of animal development. Little is known about the molecular pathways controlling HOXA1. Recent data from our group revealed distinct partner proteins interacting with HO
Autor:
Vladimir F. Lazarev, Pavel I. Semenyuk, Irina V. Guzhova, Dmitry V Sverchinsky, Boris A. Margulis, Vladimir A. Mitkevich
Publikováno v:
FEBS Letters. 591:4074-4082
Most Hsp70 chaperone inhibitors exert anti-cancer effects; however, their high cytotoxicity proposed the use of peptide fragments of the chaperone as safer modulators of its activity and as complements to customary drugs. One such peptide, ICit-2, wa
Autor:
Shunsuke Kobayashi, Fumitaka Oyama, Vaclav Matoska, Shotaro Honda, Yasusato Sugahara, Akinori Kashimura, Peter O. Bauer, Minori Kamaya, Masayoshi Sakaguchi, Masahiro Kimura, Satoshi Wakita
Publikováno v:
FEBS Letters. 591:3310-3318
Mouse acidic mammalian chitinase (AMCase) degrades chitin with highest efficiency at pH 2.0 and is active up to pH 8.0. Here, we report that mouse AMCase also exhibits transglycosylation activity under neutral conditions. We incubated natural and art
Publikováno v:
FEBS Letters. 591:2426-2438
Here, we found that formate, an essential one-carbon metabolite, activates superoxide (O2·-)/hydrogen peroxide (H2 O2 ) release from mitochondria. Sodium formate (30 μm) induces a significant increase in O2·-/H2 O2 production in liver mitochondria