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pro vyhledávání: ''
Autor:
Marios P. Stavridis, Mehmet Gundogdu, Sergio G. Bartual, Daan M. F. van Aalten, Andrew T. Ferenbach, Riina Žordania, Katrin Õunap, Veronica M. Pravata, Monica H. Wojcik, Sander Pajusalu
Publikováno v:
Febs Letters
'FEBS Letters ', vol: 594, pages: 717-727 (2020)
'FEBS Letters ', vol: 594, pages: 717-727 (2020)
X‐linked intellectual disabilities (XLID) are common developmental disorders. The enzyme O‐GlcNAc transferase encoded by OGT, a recently discovered XLID gene, attaches O‐GlcNAc to nuclear and cytoplasmic proteins. As few missense mutations have
Autor:
Naoyuki Taniguchi, Yasuhiko Kizuka, Hiromasa Inoue, Yoichiro Harada, Hirokazu Yagi, Ikuro Maruyama, Yuko Tokoro, Koichi Kato, Kiyotaka Kondo
Publikováno v:
Febs Letters
We investigated the correlation between metastatic behaviors of tumor cells and asparagine-linked glycosylation (N-glycosylation) of tumor-derived extracellular vesicles (EVs). Three mouse melanoma B16 variants with distinct metastatic potentials sho
Autor:
Mingming Xu, Jinyu Li, Peng Xu, Mingdong Huang, Peter A. Andreasen, Longguang Jiang, Yayu Chen
Publikováno v:
Xu, M, Chen, Y, Xu, P, Andreasen, P A, Jiang, L, Li, J & Huang, M 2018, ' Crystal structure of plasma kallikrein reveals the unusual flexibility of the S1 pocket triggered by Glu217 ', FEBS Letters, vol. 592, no. 15, pp. 2658-2667 . https://doi.org/10.1002/1873-3468.13191
Serine proteases play important roles in numerous physiological and pathophysiological processes. Moreover, serine proteases are classical subjects for studies of catalytic and inhibitory mechanisms of enzymes. Here, we determined the crystal structu
Autor:
Shunsuke Kobayashi, Fumitaka Oyama, Vaclav Matoska, Shotaro Honda, Yasusato Sugahara, Akinori Kashimura, Peter O. Bauer, Minori Kamaya, Masayoshi Sakaguchi, Masahiro Kimura, Satoshi Wakita
Publikováno v:
FEBS Letters. 591:3310-3318
Mouse acidic mammalian chitinase (AMCase) degrades chitin with highest efficiency at pH 2.0 and is active up to pH 8.0. Here, we report that mouse AMCase also exhibits transglycosylation activity under neutral conditions. We incubated natural and art
Publikováno v:
FEBS Letters. 591:954-961
Cyclic GMP-AMP synthase (cGAS) is a DNA-sensing enzyme in the innate immune system. Recent studies using core-cGAS lacking the N terminus investigated the mechanism for binding of double-stranded (ds) DNA and synthesis of 2',3'-cyclic GMP-AMP (cGAMP)
Autor:
Chuan Li, Tetsuya Fukui, Shinya Hasegawa, Daiki Inoue, Masahiko Imai, Noriko Takahashi, Masahiro Yamasaki
Publikováno v:
FEBS Letters. 590:1592-1601
Acetoacetyl-CoA synthetase (AACS) is a ketone body-utilizing enzyme and is responsible for the synthesis of cholesterol and fatty acids. We have previously shown that AACS is cleaved by legumain, a lysosomal asparaginyl endopeptidase. In this study,
Autor:
Cesare Montecucco, Thomas Binz, Fulvio Bordin, Ornella Rossetto, Marco Pirazzini, Clifford C. Shone
Publikováno v:
FEBS Letters. 587:150-155
Tetanus and botulinum neurotoxins cause paralysis by cleaving SNARE proteins within the cytosol of nerve terminals. They are endocytosed inside acidic vesicles and the pH gradient across the membrane drives the translocation of their metalloprotease
Autor:
Ming-Da Wen, Liangyuan Li, Chang Liu, Cai-Hua Yuan, Da-Chuan Dong, Tao Jin, Zhao Zhang, Pengyu Gu, Xiang Gao
Publikováno v:
FEBS letters. 589(23)
Our understanding of how metabolic switches occur in the failing heart is still limited. Here, we report the emblematic pattern of metabolic alternations in two different mouse models. PP2Acα deficient hearts exhibited a dramatic decrease in the lev
Autor:
Yeong-Jae Seok, Yangkyun Ryu, You-Jin Kim, Soon-Jung Park, Kyu-Ho Lee, Na Yeon Lee, Byoung-Mo Koo, Se-Jin Chun
Publikováno v:
FEBS Letters. 584:4537-4544
Vibrio vulnificus is an opportunistic human pathogen that causes severe infections in susceptible individuals. While the components of the Escherichia coli phosphoenolpyruvate: sugar phosphotransferase system (PTS) have been shown to regulate numerou
Publikováno v:
FEBS Letters. 581:4109-4114
The activity of one of the eukaryotic initiation factor 2alpha kinases, heme-regulated inhibitor (HRI), is modulated by heme binding. Here, we demonstrate for the first time that Hg2+ strongly inhibits the function of HRI (IC50=0.6 microM), and nitri