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Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Paediatrics Publications
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Paediatrics Publications
Introduction: Chagas disease (CD) is one of the most neglected public health problems in the Americas, where
Publikováno v:
Expert Review of Clinical Pharmacology. 11:537-541
Background: The dose-effect relationship of teicoplanin has been a hot topic of clinical concern, but there was lack of the evidence of Chinese patients to optimize dosage, especially in elderly critical patients, whose plasma protein, liver and kidn
Autor:
Asher Ornoy, Gideon Koren
Publikováno v:
Expert Review of Clinical Pharmacology. 11:373-385
It was assumed for decades that the human placenta serves as a barrier, protecting the fetus from exposure to xenobiotics circulating in the mother. The thalidomide disaster completely reversed this concept. The study of the human placenta is therefo
Publikováno v:
Expert Review of Clinical Pharmacology. 11:219-231
The tyrosine kinase inhibitor (TKI) imatinib was rationally designed to target BCR-ABL1 which is constitutively activated in chronic myeloid leukemia (CML). Following the tremendous success in adults, imatinib also became licensed for treatment of CM
Autor:
Arjun Vasant Balar, Michael Crist
Publikováno v:
Expert Review of Clinical Pharmacology. 10:1295-1301
Until recently, there has been little advancement in the management of invasive and metastatic urothelial cancer in over 30 years, and outcomes with cisplatin-based chemotherapy remain unchanged. Inhibitors targeting PD-1 signaling on cytotoxic T-cel
Publikováno v:
Expert Review of Clinical Pharmacology. 10:1055-1072
Introduction: Cystic Fibrosis (CF) is an autosomal recessive disease affecting up to 90,000 people worldwide. Approximately 73% of patients are homozygous for the F508del cystic fibrosis transmembrane conductance regulator [CFTR] mutation. Traditiona
Autor:
Ron Milo, Michael Osherov
Publikováno v:
Expert Review of Clinical Pharmacology. 10:1037-1047
The goal of the article is to review the mechanism of action and the use of daclizumab, a humanized monoclonal antibody (mAb) against the alpha subunit of the high affinity interleukin-2 (IL-2) receptor, in the treatment of Multiple Sclerosis (MS). A
Autor:
Monika Parisi, Corey Pelletier, Ali McBride, Qian Cai, Machaon Bonafede, Manish Patel, Oth Tran, Nicole Princic
Publikováno v:
Expert Review of Clinical Pharmacology. 10:1153-1160
The economic burden of metastatic pancreatic cancer (mPC) is substantial while treatment options are limited. Little is known about the treatment patterns and healthcare costs among mPC patients who initiated first-line gemcitabine plus nanoparticle
Publikováno v:
Expert Review of Clinical Pharmacology. 10:1239-1250
Introduction: Infections with Clostridium difficile (CDI) represent a major burden for the health care system. Treatment is generally by antibiotic therapy with metronidazole and vancomycin, but efficacy remains suboptimal.Areas covered: This review
Autor:
Emmanuelle Landmann, Ulrich A. Walker
Publikováno v:
Expert Review of Clinical Pharmacology. 10:855-864
Cryopyrin-associated periodic syndromes (CAPS) are rare monogenic autoinflammatory diseases, comprising a spectrum of phenotypes of varying severity. CAPS are associated with gain-of-function mutations in the NLRP3 inflammasome, a multiprotein comple