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Publikováno v:
Expert Opin Ther Targets
INTRODUCTION: Antipsychotic drugs that target the dopamine system have been central to the treatment of schizophrenia, but their limitations in efficacy, tolerability, and precision necessitate improved treatment strategies. Multiple lines of researc
Publikováno v:
Expert Opin Ther Targets
INTRODUCTION: Inflammasomes are central to atherosclerotic vascular dysfunction with regulatory effects on inflammation, immune modulation, and lipid metabolism. The NLRP3 inflammasome is a critical catalyst for atherogenesis thus highlighting its im
Autor:
Thanat Chaikijurajai, W.H. Wilson Tang
Publikováno v:
Expert Opin Ther Targets
Introduction Coronary artery disease (CAD) poses significant morbidity and mortality globally. Despite significant advances in treatment interventions, residual cardiovascular risks remain unchecked. Recent clinical trials have shed light on the pote
Publikováno v:
Expert Opinion on Therapeutic Targets. 24:359-378
Introduction: Age-related Macular Degeneration (AMD), a retinal neurodegenerative disease is the most common cause of blindness among the elderly in developed countries. The impairment of mitochondrial biogenesis has been reported in human retinal pi
Autor:
Paul Horn, Philip N. Newsome
Publikováno v:
Expert Opinion on Therapeutic Targets. 24:175-186
Introduction: nonalcoholic steatohepatitis (NASH) is a globally emerging health problem, mainly caused by increasing trends in the prevalence of obesity and metabolic syndrome. Patients with NASH are mainly affected by cardiovascular risk and extrahe
Autor:
Sunil Joshi, Saeed R. Khan
Publikováno v:
Expert Opinion on Therapeutic Targets. 23:379-391
Oxalate is a toxic byproduct of metabolism and is normally produced in quantities easily removed from the body. However, under specific circumstances oxalate production is increased resulting in deposition of calcium oxalate (CaOx) crystals in the ki
Publikováno v:
Expert Opinion on Therapeutic Targets. 23:407-421
Anemia is a common manifestation of chronic kidney disease (CKD). The pathogenesis of CKD-associated anemia is multifactorial. Our understanding of the molecular control of iron metabolism has improved dramatically because of the discovery of hepcidi
Autor:
Mehdi Yousefi, Mohammad Hojjat-Farsangi, Sahar Raoofi Mohseni, Ali Masjedi, Farhad Jadidi-Niaragh, Ghasem Ghalamfarsa, Gholamreza Azizi, Mohammad Hossein Kazemi
Publikováno v:
Expert Opinion on Therapeutic Targets. 23:127-142
Cancer cells apply various mechanisms to induce and enhance immune escape. The complex network of immune-response modulating factors in the tumor microenvironment is a reason for the difficulties encountered when attempting to treat many cancers. Ade
Autor:
Azam Hosseinzadeh, Rasoul Yarahmadi, Russel J. Reiter, Habib Ghaznavi, Saeed Mehrzadi, Seyed Ali Javad-Moosavi
Publikováno v:
Expert Opinion on Therapeutic Targets. 22:1049-1061
Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease associated with disruption of alveolar epithelial cell layer and expansion of fibroblasts/myofibroblasts. Excessive levels of oxidative/nitrosative stress, induction of apoptosi
Autor:
Petra Zimmermann, Nigel Curtis
Publikováno v:
Expert Opinion on Therapeutic Targets. 22:967-972
Aspirin (acetylsalicylic acid, ASA) is often co-administered during the treatment of infections. Salicylic acid (SAL), the active metabolite of ASA, has significant effects on bacteria that might improve or (more likely) compromise the effectiveness