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Publikováno v:
Expert Opin Ther Targets
INTRODUCTION: Antipsychotic drugs that target the dopamine system have been central to the treatment of schizophrenia, but their limitations in efficacy, tolerability, and precision necessitate improved treatment strategies. Multiple lines of researc
Autor:
Stefano Espinoza, I. Sukhanov, Michael D. Schwartz, Raul R. Gainetdinov, Juan J. Canales, Riccardo Zucchi
Publikováno v:
Expert Opinion on Therapeutic Targets. 22:513-526
The trace amines, endogenous amines closely related to the biogenic amine neurotransmitters, have been known to exert physiological and neurological effects for decades. The recent identification of a trace amine-sensitive G protein-coupled receptor,
Publikováno v:
Expert Opinion on Therapeutic Targets. 22:161-176
Autonomic imbalance plays a pivotal role in the pathophysiology of inflammatory bowel diseases (IBD). The central nervous system (CNS) cooperates dynamically with the immune system to regulate inflammation through humoral and neural pathways. In par
Publikováno v:
Expert Opinion on Therapeutic Targets. 21:949-958
Signal transduction at the neuromuscular junction (NMJ) is compromised in a diverse array of diseases including myasthenia gravis, Lambert-Eaton myasthenic syndrome, Isaacs' syndrome, congenital myasthenic syndromes, Fukuyama-type congenital muscular
Publikováno v:
Expert Opinion on Therapeutic Targets
Expert opinion on therapeutic targets
Expert opinion on therapeutic targets
Introduction: The ancient and ubiquitous monoamine signalling molecules serotonin, dopamine, norepinephrine, and epinephrine are involved in multiple physiological functions. The aromatic amino acid hydroxylases tyrosine hydroxylase (TH), tryptophan
Publikováno v:
Expert Opinion on Therapeutic Targets. 20:1267-1282
Introduction: Androgen receptor (AR) is a ligand-dependent transcription factor and a member of the nuclear receptor superfamily. It plays a vital role in male sexual development and regulates gene expression in various tissues, including prostate. A