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Autor:
Paul Horn, Philip N. Newsome
Publikováno v:
Expert Opinion on Therapeutic Targets. 24:175-186
Introduction: nonalcoholic steatohepatitis (NASH) is a globally emerging health problem, mainly caused by increasing trends in the prevalence of obesity and metabolic syndrome. Patients with NASH are mainly affected by cardiovascular risk and extrahe
Autor:
Petra Zimmermann, Nigel Curtis
Publikováno v:
Expert Opinion on Therapeutic Targets. 22:967-972
Aspirin (acetylsalicylic acid, ASA) is often co-administered during the treatment of infections. Salicylic acid (SAL), the active metabolite of ASA, has significant effects on bacteria that might improve or (more likely) compromise the effectiveness
Autor:
Robert Tarran, Patrick J. Moore
Publikováno v:
Expert Opinion on Therapeutic Targets. 22:687-701
Cystic fibrosis is an autosomal recessive disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene that codes for the CFTR anion channel. In the absence of functional CFTR, the epithelial Na
Publikováno v:
Expert Opinion on Therapeutic Targets. 22:161-176
Autonomic imbalance plays a pivotal role in the pathophysiology of inflammatory bowel diseases (IBD). The central nervous system (CNS) cooperates dynamically with the immune system to regulate inflammation through humoral and neural pathways. In par
Publikováno v:
Expert Opinion on Therapeutic Targets. 23:365-367
Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer, affecting 85% of patients. It is the fourth most frequent cause of cancer-related death and bound to become sec...