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pro vyhledávání: '"Arthur Kavanaugh"'
Autor:
Swapna Busa, Arthur Kavanaugh
Publikováno v:
Expert opinion on drug safety. 14(6)
Apremilast is an orally available small molecule that targets PDE4. PDE4 modulates intracellular signaling and thereby can impact various proinflammatory and anti-inflammatory mediators. Apremilast has been approved by the USA FDA for the treatment o
Autor:
Arthur Kavanaugh, Hong Yang
Publikováno v:
Expert opinion on drug safety. 13(1)
A number of new biological immune modulators have become available as treatments for inflammatory diseases over the past two decades. Most prominent among them are TNF-α inhibitors (TNFi) which have been available in the clinic since the late 1990s.
Autor:
Edward C. Keystone, Arthur Kavanaugh
Publikováno v:
Expert opinion on drug safety. 4(2)
The introduction of TNF inhibitors into the clinic for the treatment of patients with rheumatoid arthritis and other systemic inflammatory conditions has revolutionised the approach to these diseases. Despite the substantial efficacy of these agents,