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Autor:
Björn Andersson, Milene Höehr de Moraes, Glauber Wagner, Carime Lessa Mansur Pontes, Patrícia Hermes Stoco, Edmundo C. Grisard, Débora Denardin Lückemeyer
Publikováno v:
Experimental parasitology. 230
Trypanosoma rangeli is a non-virulent hemoflagellate parasite infecting humans, wild and domestic mammals in Central and Latin America. The share of genotypic, phenotypic, and biological similarities with the virulent, human-infective T. cruzi and T.
Autor:
Patricia Andrea Garavaglia, Gabriela Andrea Garcia, Joaquin Juan Bautista Cannata, Cristina Graciela Maidana, Juan Matías Viecenz, Laura Mónica Tasso
Publikováno v:
Experimental parasitology. 231
Dihydroxyacetone (DHA) can be used as an energy source by many cell types; however, it is toxic at high concentrations. The enzyme dihydroxyacetone kinase (DAK) has shown to be involved in DHA detoxification and osmoregulation. Among protozoa of the
Autor:
Carolina Dale, Max Jean de Ornelas Toledo, Miyoko Massago, Silvana Marques de Araújo, Nilma de Souza Fernandes, Ana Paula de Abreu, Cleber Galvão, Ana Paula Margioto Teston, Hevillyn Fernanda Lucas da Silva, Érika Cristina Ferreira
Publikováno v:
Experimental Parasitology. 232:108197
Vector competence of triatomines (kissing bugs) for Trypanosoma cruzi transmission depends on the parasite-vector interaction and the genetic constitution of both. This study evaluates the susceptibility and vector competence of Rhodnius robustus exp
Autor:
Jacqueline Bua, Natalia Milduberger, Miriam Postan, Patricia Bustos, Alina Elizabeth Perrone, Carolina González
Publikováno v:
Experimental parasitology. 220
Trypanosoma cruzi is the causative agent of Chagas disease, which is endemic in Latin America and around the world through mother to child transmission. The heart is the organ most frequently affected in the chronic stage of the human infection and d
Autor:
Cinthia Melazzo de Andrade, Dionatan Teixeira de Oliveira, Marjorie de Giacommeti, Silvia Gonzalez Monteiro, Ana Martiele Engelmann, João Cândido Pillar Mayer, Luciano Dornelles, Antônio Francisco Igor Magalhães de Matos, Litiérria Razia Garzon, Matheus D. Baldissera, Letícia dos Santos Petry
Publikováno v:
Experimental parasitology.
Chagas disease, caused by Trypanosoma cruzi, is a major public health problem and is described as one of the most neglected diseases worldwide. It affects about 6-7 million people. Currently, only two drugs are available for the treatment of this dis
Autor:
Kátia da Silva Fonseca, Bruno Mendes Roatt, Thais Vieira de Carvalho, Aline Tonhela Ferraz, Levi Eduardo Soares Reis, Flávia de Souza Marques, Lívia M. Carvalho, Cláudia Martins Carneiro, Paula Melo de Abreu Vieira
Publikováno v:
Experimental parasitology. 218
Chagas disease, caused by the protozoan Trypanosoma cruzi, is endemic in almost all countries of Latin America. In Brazil, oral infection is becoming the most important mechanism of transmission of the disease in several regions of the country. The g
Autor:
Max Jean de Ornelas Toledo, Nilma de Souza Fernandes, Marcella Paula Mansano Sarto, Camila Piva Abegg, Mônica Lúcia Gomes, Ana Paula de Abreu, Ana Paula Margioto Teston
Publikováno v:
Experimental parasitology. 228
Strains of Trypanosoma cruzi, etiological agent of Chagas disease, are classified into different discrete typing units that may present distinct dynamics of infection and susceptibility to benznidazole (BZ) treatment. Mice that were orally inoculated
Autor:
Lívia M. Carvalho, Cláudia Martins Carneiro, Paula Melo de Abreu Vieira, Thais Vieira de Carvalho, João Vitor Madeira, Kátia da Silva Fonseca, Rodrigo Correa-Oliveira, Israel Molina, Luciana da Fonseca Medeiros, Luísa Perin
Publikováno v:
Experimental parasitology. 210
Studies suggest that the dose of the standard benznidazole (BNZ) treatment regimen might be too high. We investigated the efficacy of BNZ 20 and 40 mg/kg/day compared with standard dose (100 mg/kg/day) to induce cure in mice infected with Trypanosoma
Publikováno v:
Experimental Parasitology. 185:92-97
Chagas disease (CD), caused by Trypanosoma cruzi, remains a serious public health problem. One of the causes of the high morbidity and mortality in patients is the lack of an effective drug therapy. Thus, the aim of this study was to evaluate the eff
Autor:
Gabriel Antonio Nogueira Nascentes, Karen A Norris, Gustavo Caetano Silva, Luis Eduardo Ramirez, Wendell Sérgio Ferreira Meira, Tatiane Marques, Priscila Moraes Henrique Paiva
Publikováno v:
Experimental Parasitology. 184:103-108
Experimental Chagas disease has been used as a model to identify several host/parasite interaction factors involved in immune responses to Trypanosoma cruzi infection. One of the factors inherent to this parasite is the complement regulatory protein