Zobrazeno 1 - 10
of 40
pro vyhledávání: ''
Autor:
Cinthia Melazzo de Andrade, Dionatan Teixeira de Oliveira, Marjorie de Giacommeti, Silvia Gonzalez Monteiro, Ana Martiele Engelmann, João Cândido Pillar Mayer, Luciano Dornelles, Antônio Francisco Igor Magalhães de Matos, Litiérria Razia Garzon, Matheus D. Baldissera, Letícia dos Santos Petry
Publikováno v:
Experimental parasitology.
Chagas disease, caused by Trypanosoma cruzi, is a major public health problem and is described as one of the most neglected diseases worldwide. It affects about 6-7 million people. Currently, only two drugs are available for the treatment of this dis
Autor:
Max Jean de Ornelas Toledo, Nilma de Souza Fernandes, Marcella Paula Mansano Sarto, Camila Piva Abegg, Mônica Lúcia Gomes, Ana Paula de Abreu, Ana Paula Margioto Teston
Publikováno v:
Experimental parasitology. 228
Strains of Trypanosoma cruzi, etiological agent of Chagas disease, are classified into different discrete typing units that may present distinct dynamics of infection and susceptibility to benznidazole (BZ) treatment. Mice that were orally inoculated
Autor:
Lívia M. Carvalho, Cláudia Martins Carneiro, Paula Melo de Abreu Vieira, Thais Vieira de Carvalho, João Vitor Madeira, Kátia da Silva Fonseca, Rodrigo Correa-Oliveira, Israel Molina, Luciana da Fonseca Medeiros, Luísa Perin
Publikováno v:
Experimental parasitology. 210
Studies suggest that the dose of the standard benznidazole (BNZ) treatment regimen might be too high. We investigated the efficacy of BNZ 20 and 40 mg/kg/day compared with standard dose (100 mg/kg/day) to induce cure in mice infected with Trypanosoma
Publikováno v:
Experimental Parasitology. 185:92-97
Chagas disease (CD), caused by Trypanosoma cruzi, remains a serious public health problem. One of the causes of the high morbidity and mortality in patients is the lack of an effective drug therapy. Thus, the aim of this study was to evaluate the eff
Autor:
Matheus Brasil da Silva, Ana Maria Antonello, Josiane Somariva Prophiro, Phileno Pinge-Filho, Onilda Santos da Silva, Pedro R. T. Romão, Ralf Heermann, Thaís Sartori
Publikováno v:
Experimental parasitology. 204
Only two drugs are currently available for the treatment of Chagas disease and their effectiveness are unsatisfactory. Photorhabdus luminescens and Xenorhabdus nematophila, two enteric bacteria highly pathogenic to a broad range of insects, have been
Publikováno v:
Experimental parasitology. 206
Phospholipids are the main component of membranes and are responsible for cell integrity. Alkylphospholipid analogues (APs) were first designed as antitumoral agents and were later tested against different cell types. Trypanosoma cruzi, the Chagas di
Autor:
Daniela Ferreira Nunes, Ludmila Ferreira de Almeida Fiuza, Cynthia Machado Cascabulho, Maria de Nazaré Correia Soeiro, Denise da Gama Jaen Batista, Otacilio C. Moreira
Publikováno v:
Experimental Parasitology. 221:108061
Chagas disease (CD) caused by Trypanosoma cruzi remains a serious public health problem in Latin America. The available treatment is limited to two old drugs, benznidazole (Bz) and nifurtimox, which exhibit limited efficacy and trigger side effects,
Publikováno v:
Experimental Parasitology. 156:26-31
Therapy against Trypanosma cruzi relies on only two chemically relatednitro-derivative drugs, benznidazole and nifurtimox, both limited by poorefficacy and toxicity. It is suspected that with prolonged usage of these drugs, resistant parasites will b
Autor:
Míriam Paula Alonso Toldo, Daniele da Silva Ferreira, Viviane Rodrigues Esperandim, Sergio de Albuquerque, Wilson Roberto Cunha, José Clóvis do Prado Júnior, Christian Collins Kuehn, Márcio Luis Andrade e Silva
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Reduction in the parasitemic levels of the Y strain of Trypanosoma cruzi in mice treated with oral or intraperitoneal ursolic (UA) and oleanolic (OA) acids was evaluated during the acute phase of Chagas' disease. Oral administration of UA and OA (50m
Autor:
Alejandrina Rodríguez-Hernández, Oxana Dobrovinskaya, Ivan Delgado-Enciso, Valery Melnikov, Gabriela Rueda-Valdovinos, Cristina Wookee-Zea, Francisco Espinoza-Gómez, Juan Salvador Valle-Reyes, Víctor Pimientel-Rodrigez, Uriel A López-Lemus
Publikováno v:
Experimental parasitology. 172
Chagas' disease is caused by unicellular parasite Trypanosoma cruzi (T. cruzi). It is endemic throughout Latin America, but nowadays has become a global challenge due to tourism and migration. Non-treated infection may result in health-threatening co